RadioLab, More Perfect, Snap Judgment, The Moth, Car Talk, This American Life, Stuff You Should Know, Hardcore History, Common Sense, Invisibilia, 99% Invisible, Planet Money - these are all great, but pretty well known.
RISK! - @ risk-show.com. I can't recommend this one enough. The host is a bit annoying, but you only have to listen to him for < 5 min/ 1 hour show. Their tag line is, "People telling true stories they never thought they would dare to share." Mostly comics and actors telling true stories in early years, now with more normal folk telling stories. Most are funny as hell, but there are some HEAVY episodes.
Sick and Wrong - Hilarious show. Started out as a show where listeners called in the sickest and wrongest news stories of the past week. Turned into ^ plus a couple of guys sitting around BSing and getting drunk. If you are a SJW, need trigger warnings, or consider yourself politically correct, then this one is absolutely not for you. Probably only good for people with a dark sense of humor. The first 500 or so episodes with Lance Wackerle are better than the most recent ones, IMO.
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