Results 14,101 to 14,125 of 23206
-
09-27-2021, 12:29 PM #14101
I thought it was alternarrative?
As in 'alternarrative facts'.
No?Merde De Glace On the Freak When Ski
>>>200 cm Black Bamboo Sidewalled DPS Lotus 120 : Best Skis Ever <<<
-
09-27-2021, 12:46 PM #14102Banned
- Join Date
- May 2007
- Location
- Sandy, Utah
- Posts
- 14,410
-
09-27-2021, 12:53 PM #14103
Find a post of mine where I criticized to the Israeli study, or any study, for not being peer reviewed? Not only that, but I was the first person here to decribe the Israeli study and discuss its limitations (without mentioning peer review.)
Now we have better data. In case you missed it yesterday or the month before, in contrast with the observational Israeli study and contrary to your lies that people here are ignoring prior infection, the best available data comes from the UK where they are doing randomized testing at the population level.
In an ongoing randomized trial with over 300K people involving regular testing to determine both vaccine immunity and natural immunity during Delta, mRNA vaccine immunity performs better than natural immunity.
The blue column contains mRNA vaccinated numbers, the yellow AZ, the green column contains unvaccinated but tested positive in the past:
Attachment 386886
The chart shows mRNA > previous infection > AZ against a low viral burden. Whereas against a high viral burden all vaccinated people had fewer symptoms when a breakthrough infection occurred compared with previous infection.
https://www.medrxiv.org/content/10.1...237v1.full.pdf
-
09-27-2021, 12:53 PM #14104
No one is forcing you to be here
Sent from my iPhone using TGR Forums
-
09-27-2021, 12:55 PM #14105
When one is offered as data and the other offered as proof, maybe there's a difference?
It's easy to get mixed up between Old Uncles and New Aunts.Merde De Glace On the Freak When Ski
>>>200 cm Black Bamboo Sidewalled DPS Lotus 120 : Best Skis Ever <<<
-
09-27-2021, 01:16 PM #14106
I’m not tied up in fee for service. I wish we could have Medicare for all with no need for supplements. The problem with Medicare advantage is that the people that work for them lead you with questions about health conditions that they can then increase your risk score to get more money even if you don’t have increased risk.
Sent from my iPhone using TGR Forums
-
09-27-2021, 01:24 PM #14107
You are free to go.
You are not owed anything here.
Life isn’t fair.
Sorry your parents never taught you these things^
But if you reread what I just said and let it sink in and really embrace it you may just become less of a thread cunter and troll.
Or don’t - you can still leave though - no one will stop you. No one is required or responsible for stopping you. No one has to want you to be here. This is not a special snowflake zone with participation ribbons for everyone.
-
09-27-2021, 01:49 PM #14108
What are you talking about? It's not like the Atlantic is Breitbert. I can't think of any mainstream news media that has done a better and more thorough job of explaining COVID science than the Atlantic. Ed Yong won the 2021 Pulitzer for his reporting on COVID science in the Atlantic. I'm not a scientist, nor do I pretend to be, just like the vast majority of earth (and TGR). I read the Atlantic, NY Times, and TGR, which makes me more informed on this stuff than the majority of Americans. I don't read peer reviewed studies because I rely on places like the Atlantic to summarize the most pertinent studies. If a scientist can't explain something to an Atlantic or NY Times audience, then they have failed. If you guys want to only discuss peer reviewed studies, TGR is not the place.
-
09-27-2021, 01:50 PM #14109Banned
- Join Date
- May 2007
- Location
- Sandy, Utah
- Posts
- 14,410
I wasnt saying YOU personally did, but it seems if you post a non peer reviewed study, thats not the FIRST fucking thing called out, more like...oh MV cool study.....someone else posts one, That might or might not refute or disagree or provide new evidence to counter yours, its instantly called out. that, to me is amusing as fuck and quite telling to how its "my way or you're plain wrong, no matter what data you provide, you're WRONG" lol
-
09-27-2021, 01:53 PM #14110
^ I think you're overstating the peer review thing. People jumped on that fact because the Israeli study keeps coming up. These things take on a life of their own. After a while people get tired of saying it's an observational study and the study's own authors' describe its limitations. Not to mention more recent data from Israel has since superseded it.
I thought the articles were fine but that the byline was the most important takeaway: Research can tell us only so much. The rest is a waiting game. The article was published in June and we know more now.
We'll know more in the future. The good news is, while we may see recommendations for an additional dose due to close spacing between the first two, it doesn't look like it will become a regular thing. Most people probably don't need a boost as things stand now.
-
09-27-2021, 01:54 PM #14111
Maybe "exhaust your immune system" is not the best way to describe it. But I assume there is such a thing as too much mRNA or any vaccine? Isn't the whole point of trials, besides determining if the vaccine is actually effective, is to fine tune the dose. More than is necessary will increase the chances for side effects. That's why the clinical studies on children are testing a much smaller dose than what is given to adults. Am I wrong about this?
-
09-27-2021, 02:06 PM #14112
No you're not wrong. While there probably isn't much harm in widely spaced boosters there are already studies showing an upper limit on what they can do.
WRT the two big concerns in the Atlantic article 1) memory lapse and 2) Virus mutations, so far so good. The vaccines generate a good memory response and work against all the know variants.
“A change in the spike protein- which allows the coronavirus to enter and infect human cells- that is radical enough to make our vaccine completely ineffective would also, almost certainly, be so extreme as to make the virus non-functional.” - Sarah Gilbert, Oxford Team
-
09-27-2021, 02:11 PM #14113______
- Join Date
- Aug 2020
- Posts
- 1,218
-
09-27-2021, 02:12 PM #14114
Note that the first and only person to directly refer to MVs 'New Study' is that puerile puppy, doggiestyle?
So no one extolled it's virtue or claimed it as proof of anything.
w00f w00f!Merde De Glace On the Freak When Ski
>>>200 cm Black Bamboo Sidewalled DPS Lotus 120 : Best Skis Ever <<<
-
09-27-2021, 02:22 PM #14115
-
09-27-2021, 02:23 PM #14116
Primary sources are more accessible than they've ever been. If you need a translator so be it, but don't act like an editorial synopsis should get more consideration. The bullshit thing was kind of a joke, though, don't take it too seriously.
In any case, would you actually conclude that more vaccine is worse than more disease, even WRT immune "overdose?" Would you rather err to the vaccine side while exposure risk remains high, even just for less over-exercise of the immune system?
-
09-27-2021, 02:25 PM #14117
-
09-27-2021, 02:30 PM #14118
No, it means the virus wouldn't be capable of infecting human cells and would therefore become incapable of replicating.
-
09-27-2021, 02:37 PM #14119
So delta=peak spike efficiency or close enough to it that any other "improvements" are still recognizable, right?
What does that say for vaccine adjustments? No need to bother, or might as well do it because the spike should stay even more stable from here on?
-
09-27-2021, 02:38 PM #14120
-
09-27-2021, 02:49 PM #14121
Yes, Delta (so far) is peak replicability. The issue with Delta is its kinetics, not its ability to escape the vaccine. After antibodies wane it takes 3-to-5 days for B cells to make more and during that time Delta is replicating like a mutha-fk'r. In spite of that, it's like a 10% drop in efficacy which means a vaccine trained immune system still wins but it's against a tougher opponent.
Delta's kinetics explains why some people have rough go of it when they experience a breakthrough infection and why older or immunocompromised people need circulating antibodies rather than depending on their immune memory response.
Even though he says the vaccines work against Delta, the computational biolgist Trevor Bedford thinks we should make vaccine adjustments tailored to Delta because any future strains capable of reducing vaccine efficacy even more will likely emerge from a Delta sublineage. Any vaccine adjustments would probably leave the spike protein elements intact and then add additional components targeted at other parts of the virus.
-
09-27-2021, 02:50 PM #14122
-
09-27-2021, 03:11 PM #14123
-
09-27-2021, 03:16 PM #14124
My understanding is trials would still be necessary to test efficacy but would be more streamlined because regulators would be less concerned about safety. I hate to make an influenza shot comparison b/c it's not the same thing but we can sort of think about it like that in terms of safety.
-
09-27-2021, 03:18 PM #14125
Bookmarks