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11-25-2021, 02:18 PM #17276Registered User
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https://www.cbc.ca/radio/quirks/nov-...d-19-1.6254091
some interesting science from Quirks and Quarks, why do some people not get infected ?Lee Lau - xxx-er is the laziest Asian canuck I know
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11-25-2021, 08:19 PM #17277Registered User
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- Idaho
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NYT -JOHANNESBURG — Scientists in South Africa identified on Thursday a concerning new variant of the coronavirus, whose mutations mark a “big jump in evolution” that is driving a spike in new cases. Hours later, Britain banned flights from six southern African nations citing the variant.
In the past two days, scientists detected the B1.1.529 variant after observing an increase in infections in South Africa’s economic hub surrounding Johannesburg. So far, 22 positive cases have been identified in the country, according to South Africa’s National Institute for Communicable Diseases. One case has been detected in Hong Kong from someone who had traveled from South Africa. No cases have been detected yet in Britain.
https://www.nytimes.com/live/2021/11...sters-mandates
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11-25-2021, 08:32 PM #17278
https://www.vice.com/en/article/v7dd...rce=reddit.com
QAnon's 'Queen of Canada' Calls for Followers to 'Kill' People Vaccinating Children
“Shoot to kill anyone who tries to inject Children under the age of 19 years old with Coronavirus19 vaccines/ bioweapons or any other Vaccines,” she wrote. “This order is effective immediately.”
Didulo has made separate pages to vet prospective members of her Canadian and U.S. duck-hunting teams to help with her mission. The Canadian group currently has just over 100 members, including the man who posted the images of the firearms. Inside the chatroom one of the duck hunters shared information about a specific vaccine popup in an Ontario mall “specifically targeting young children.”
“It’s time to react now,” replied one person. “Hurry up and wait is no longer the thing to say.”
Her followers are pledging their support to their Queen’s initiative. “A few duck hunters coming in can stay with me… I’m ready… all my hunting gear is ready… let’s roll,” wrote one in the public chat and posted a picture of firearms strewn across a table.
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11-25-2021, 09:07 PM #17279Registered User
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- Oct 2010
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- 315
Fucking canadiens. Happy thanksgiving
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11-25-2021, 09:16 PM #17280
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11-25-2021, 09:50 PM #17281
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11-25-2021, 09:55 PM #17282
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11-25-2021, 10:07 PM #17283
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11-25-2021, 10:13 PM #17284
I thought Canuckistan had better mental health care than the US?
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11-25-2021, 11:10 PM #17285Registered User
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yeah so that republic stuff is and the whole we the people thing is so American wanabe,
Canada is a Constitutional Monarchy eh
but in view of the TG gatherings, in 10 days we should see the bump in Covid infections ?Lee Lau - xxx-er is the laziest Asian canuck I know
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11-25-2021, 11:41 PM #17286
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11-26-2021, 09:58 AM #17287one of those sickos
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- Oct 2005
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ride bikes, climb, ski, travel, cook, work to fund former, repeat.
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11-26-2021, 10:29 AM #17288
They do. Apparently they also have better writing skills.
A similar group with a similar message in the US would just be some Twitter rant someone else happened to film and post.
Sent from my iPhone using TGR Forums
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11-26-2021, 10:34 AM #17289
So... who's up to date on the latest S. African variant?
Merde De Glace On the Freak When Ski
>>>200 cm Black Bamboo Sidewalled DPS Lotus 120 : Best Skis Ever <<<
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11-26-2021, 10:39 AM #17290
Already in hongkong and belgium.
The europe case is an unvaxxed traveler! Here we go again. Thanks antivaxxers
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11-26-2021, 10:42 AM #17291
What I am gathering is it’s very new and still sorting things out as to transmission, vaccine resistance and severity. Bunch of European nations are stopping folks coming in from parts of Africa. You probably knew this, but going to take a bit to sort it out.
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11-26-2021, 10:54 AM #17292
The two questions I have are: how transmissible and how susceptible to existing vaccines?
Merde De Glace On the Freak When Ski
>>>200 cm Black Bamboo Sidewalled DPS Lotus 120 : Best Skis Ever <<<
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11-26-2021, 10:58 AM #17293
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11-26-2021, 11:07 AM #17294
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11-26-2021, 11:10 AM #17295
Shantytown inhabitants jetting to Hong Kong and Belgium? Holy socioeconomic jumps batman.
Merde De Glace On the Freak When Ski
>>>200 cm Black Bamboo Sidewalled DPS Lotus 120 : Best Skis Ever <<<
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11-26-2021, 11:10 AM #17296
DOW is down a thousand and still crashing over fears that the new variant and its mutants have skipped past the vaccines available worse than Delta. I think it's way too soon to say that's true but people are definitely panicking.
Go that way really REALLY fast. If something gets in your way, TURN!
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11-26-2021, 11:13 AM #17297
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11-26-2021, 11:16 AM #17298
Why I am less nervous: these same concerning anecdotes were present during the Beta surge (Beta South African B.1.351). South African sources echoed quite loudly on the subject:
- There was much talk of reinfection cases.
- There was in vitro reduced neutralizing activity studies that had people up in arms.
- There was great concern of vaccine escape.
So what actually happened since the world didn't end?
- No epidemiologically meaningful reinfection data was ever shown.
- The in vitro experiments didn't transfer over to in vivo and epidemiologically significant effects for pandemic control.
- The vaccine concerns ended up being that the AZ vaccine used in SA was subpar in VEI realworld performance, but still protected extremely well against severe disease.
Beta was not the "Omega strain" feared, nor was its equally supposedly-fearsome cousin Gamma (P.1 Brazil) a terror outside of its emergent region which had the same fears, anecdotes, and in vitro data as Beta. Lambda and Mu were going to do us in as well. Alpha (UK B.1.17), the less fearsome though still more virulent and contagious than Wild Type, ended up being the worldwide dominant strain until Delta (India B.1.617) decisively outcompeted every other strain across the globe.
Will New Omicron (Botswana/South Africa B.1.1.529) be the immunity escaping Omega strain?
Why I am nervous: concerning anecdotes from SA about immune escape and presumed high seroprevalence in the region, maybe 40% maybe 70% while vaccine uptake is just over 20%. South Africa had it bad, about as bad as anywhere and the situations in their hospitals were just gut wrenching for patients and staff. The issue is of course that there are localized bursts in incidence that follow a mutation of better reproductive fitness which could be similar to Alpha and Delta, but not necessarily immune escape, or it could mean some level of immune escape. We have alterations in areas of the spike protein that could compromise previous infection immunity, vaccine response, and even multicompartment immunity... but will eyeballing a protein/sequence and computer simulation equal reduced activity in vitro? In vivo? Meaningfully so? For those previously infected? For those vaccinated? How about for those boosted? It could be with this many mutations that much of the previous vaccine efficacy will be muted, at least for infection. We won't know for 2-4 weeks.
When 1918 H1N1 Paninfluenza went around the world in several waves over the 2+ years of that pandemic, it mutated into more strains than SARS-CoV-2. There was no vaccine, or even real understanding that it was a virus. People were reinfected because the new strains were mutated to the point of immune escape because that is what Influenza virus does best, much better than COVID. But the immune memory was not truly blind. The people who were infected previously had a much milder course and the second time around, and that wasn't simply regression to mean virulence through mutation.
What is clear is that like Delta, "Omicron" emerged in a low vaccination region. Mutations come from replications. The only way to cut replications is to prevent infections. The only way to prevent infections long term is vaccinations. Luckily, with mRNA technology, Moderna and Biontech could start the production of a tuned up booster shot next week. Vaccine producers already have done work on this. If we treat approval as we do seasonal influenza shots, deployment could be faster than the virus moving forward. Similarly, we can generate monoclonal antibody treatments rapidly. Lastly, new protease inhibitor antiviral drugs such as those from Pfizer and Merck conceptually seem unlikely to be affected by RBD mutations as these don't play into the drugs mechanism (the proteases won't change). So, even at worst case, this won't be a "new pandemic," but something similar or worse than Delta's terrible impact while we mitigate with drugs and non-pharmaceutical interventions until a new booster is deployed. Best case, this is a nothingburger. I am hopeful that immunity from vaccine and previous infection will have preserved efficacy against sever disease.Last edited by Summit; 11-26-2021 at 01:36 PM.
Originally Posted by blurred
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11-26-2021, 11:21 AM #17299
Is there any evolutionary purpose of disease? One hypothesis as to why some are so effected by COVID, and some are asymptomatic, is because of previous exposure to corona viruses. What's better, playing wack a mole with vaccines while new variants continually pop out from places without the same access to the vaccines, or just letting it run rampant trying to build worldwide immunity as quickly as possible? I think we will need 50 years to sort out the true answer to this question.
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11-26-2021, 11:27 AM #17300
I still have a pretty robust supply of "good" masks. The folks who should be most worried about any new strain spreading wildly are the ones who refuse to wear masks around other people indoors. So, again those folks will be the ones suffering most along with the healthcare workers stuck trying to save them from their own ignorance/stubbornness. Betting science can crank out an updated vaccine within a year again., but back to masks everywhere all the time until then for smart people if it's confirmed vaccines are way less effective at preventing serious illness from this.
Go that way really REALLY fast. If something gets in your way, TURN!
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