Results 9,301 to 9,325 of 23206
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08-17-2021, 10:42 AM #9301
Montucky is still around - he is reading these posts.
Meanwhile Florida and Texas are getting their asses kicked. Posts about “well this state is worse by this metric!” or “I don’t see it happening around me” are to be expected from idiots.
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08-17-2021, 11:11 AM #9302
While none of the vaccines can be made to be specific for the mutation that makes Delta unique and contributes to the increase in transmissability, we know the existing vaccines afford significant protection already. So to the extent that the current vaccines can perform better, the answer is likely yes. For example, several groups are exploring how changing the interval between first and second dose effects the level of antibodies and T cells created. For Pfizer, changing from the 21-42 interval between shots currently used here in the states to 72 days looks like it could help.
https://www.businessinsider.com/dela...e-study-2021-7
The trade off of course is that you have more people walking around single-dose protection for an additional 30 days.
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08-17-2021, 11:29 AM #9303click here
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08-17-2021, 11:34 AM #9304Registered User
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Pretty grim article with good reason.
An excerpt below:
"What is clear is that “breakthrough” cases are not the rare events the term implies. As of 15 August, 514 Israelis were hospitalized with severe or critical COVID-19, a 31% increase from just 4 days earlier. Of the 514, 59% were fully vaccinated. Of the vaccinated, 87% were 60 or older. “There are so many breakthrough infections that they dominate and most of the hospitalized patients are actually vaccinated,” says Uri Shalit, a bioinformatician at the Israel Institute of Technology (Technion) who has consulted on COVID-19 for the government. “One of the big stories from Israel [is]: ‘Vaccines work, but not well enough.’”
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08-17-2021, 11:38 AM #9305
That hasn't been studied afaik. Three dose regimens aren't new and are standard for Hep B and optional for HPV. They are however, usually spaced out a little further than 10 weeks presumably to avoid overlap with the innate response and provide extended time for establishing B and T populations. For example, the HPV 3-dose schedule is 0, 1–2 and then 6 months. Similarly, Hep B is 0, 1 to 2 months, and 4 to 6 months.
I'm not an immunologist, so others will likely have a more informed view.
Also consider the drop in adherence between a 2-dose and 3-dose regimen. Bigger picture issue for managing population-wide spread.
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08-17-2021, 11:40 AM #9306
The tourist element is strong too. Everyone cramming post vaccine / pre school year vacations in.
Just got back from Hawaii and the place was 100% full with about 30% indoor mask compliance from tourists even though there is an indoor mask mandate.
I get on an elevator with 6 people and maybe 1 have a mask on. Annoying.
TSA line to get out of Maui was 2hrs long and wife tracked 1 mile on her Fitbit.
https://www.nytimes.com/interactive/...vid-cases.html
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08-17-2021, 11:40 AM #9307click here
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Seems a bit extreme. Build a stack of litmus tests and you'll have no employees, or friends. We're all humans with differing experiences and beliefs. Except in the case where the assistant might be deciding Covid policy. And even then how's changing their Covid policy any different than any other policy the GC may adjust. Surely the assistant is good at every other task, and a valuable team member. Possibly more valuable now, as you now know they are willing to raise controversial topics.
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08-17-2021, 11:44 AM #9308
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08-17-2021, 11:47 AM #9309
X
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08-17-2021, 11:52 AM #9310
Ok, doomer.
They're working great in Ontario. Difference here is most had to wait 4 weeks between doses, and many of us mixed brands (because who cares about what brand your vaccine is, anyway?). If only we could get the rest of the 'wait and see' dolts done, and then the kids we'd be (somewhat) smooth sailing. Did you get your vaccine yet?
Today's (17th August 2021) cases by Vaccines��
Vaccine Effectiveness: 84.66%
None Partial Full Unknown
Cases 203 49 79 17
Hospitalization 61 7 14 -
ICU 49 5 3 -
Cases per 100K
Cases per 100K with no vaccine 8.15
Cases per 100K with partial vaccine 4.22
Cases per 100K with Full vaccine 1.25
Overall per 100K: 3.55
7-day Average:
Date Cases Hosp. ICU
1 Dose 2 Dose 1 Dose 2 Dose 1 Dose 2 Dose
As of Aug 17 -50.9% -86.5% -58.1% -97.5% -62.0% -92.7%
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08-17-2021, 11:53 AM #9311
Teeny tiny bit of hope? (With a turd lining)
https://www.latimes.com/california/s...hallenge-loomsForum Cross Pollinator, gratuitously strident
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08-17-2021, 11:58 AM #9312
Sorry if already posted. WY military will likely impose mandates.
https://buckrail.com/wyoming-militar...ccine-mandate/Forum Cross Pollinator, gratuitously strident
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08-17-2021, 12:00 PM #9313Registered User
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Funny, our leading expert in the USA disagrees with your statement above.
https://fortune.com/2021/08/12/covid...o-is-eligible/
“It is preferable you go with the same brand,” Fauci said. “You will be hearing instructions about that from the FDA [and] through the CDC."
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08-17-2021, 12:07 PM #9314
I'm not sure the why for this recco except that Fauci has been pretty focused on "if the studies tested this way (Pfizerx2 gets Pfizer booster), then we have data for this way, and we should do it this way because we already shoot from the hip more than we want." It is the same reason we stuck to the dose spacing from the Phase III trials while some other countries decided to make up a new plan that varied from the study protocol based on a visit from the good idea fairy. Well, in this case, it seems that was a good decision for UK and Canada. Many of us felt "this is EUA approved based on the study data with a strict protocol, so let's not just change the process so that the safety and efficacy data may not match what we are actually doing." Well, new data, new plan, hooray!
I haven't been able to watch the 8/13 ACIP meeting recording, probably will have discussion...Originally Posted by blurred
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08-17-2021, 12:25 PM #9315
Absolutely possible, akin to how the Flu vax can change change each year to try and be more specific to the dominant circulating strains. Even easier with mRNA as it's just a few base pairs of change in the mRNA backbone. But, we are also moving the bar from "protection against severe disease and hospitalization" to "prevention of infection and reduction of transmission" in the population at whole.
The former mobilizes different arms of immunity (innate signaling, t cell, mem b cell, and new burst of antibodies) that respond more rapidly due to immune memory in a second exposure. The current vaccines are still doing this, and like several vax's they tend to work better in a larger % of the vaccinees when using 3 dose regimens v. 2 or 1 dose vaccines.
Prevention of Infection needs high quantities of circulating and mucosal neutralizing antibody that will bind virus and prevent it from getting inside a cell to replicate. Delta complicates the latter in 2 ways:
It has drifted in it's Spike enough lower the % of the antibodies that were able to neutralize the first wave strain that remain able to bind and neutralize Delta and also lowers the % of previously infected or vaccinated people that have enough remaining neutralizing Abs to block a Delta infection. These circulating Nab levels decline over time as well, so a booster with a "Delta" variant could address this part.
More insidious, it has sped up it's entry process into a cell significantly, both with changes in it's affinity for Ace2 and by having the majority of it's Spike proteins pre-primed by enhanced furin cleavage due to the P681R mutation. This means there is less time for antibodies to find and bind the virus in a way that blocks entry, and therefore chances of obtaining prevention of infection are reduced. Herd immunity goes from a hopeful 60-70% population coverage to ~90%.
Given the really low Ct values with Delta and ~2 days earlier than the reference strain (d4v d6), the inference is not only faster entry into a cell but also faster replication, and also increased virus shedding. This could mean it takes less Delta to initiate an infection. This could also mean that Delta is worse because higher average initial exposures means it is harder for the to limit replication leading to disease progression. Or both are possible. So far limited data suggests Delta may be more likely to cause sickness vs remaining asymptomatic following exposure, but not more likely to cause severe disease/hospitalization death. To an extent that this may be due with infection demographics being younger for Delta and higher % of vaccine uptake in the 65+.
From my personal science-y perspective, I sort of anticipated mutation that would be towards escape from neutralization and host attempts to clear the virus, but that vaccine immunity would still persist, and boosters would likely be needed at some interval of drift. I mentioned the initial furin cleavage site was still suboptimal, but it's surprising the extent the virus has been able to mutate in some strains to supress innate immune signaling, or to alter it's kinetics to speed up it's growth and transmission rates.Move upside and let the man go through...
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08-17-2021, 12:31 PM #9316
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08-17-2021, 12:38 PM #9317
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08-17-2021, 12:42 PM #9318
Even though the antivaxx crowd is having field day with Israel, the vaccines are doing a really good job—just not as spectacular as before—in Israel too. Comparing infection and disease rates (per 100k) and not just raw counts to compare unvaccinated and vaccinated groups shows high efficacy protecting against severe disease, even for Delta, and even in Israel.
Israel data as of August 15, 2021 broken out by age group:
Attachment 382640
Antivaxxers' are going to antivaxx. It seems pandemic intervention skeptics however should be praising the vaccines from rooftops and arguing for universal vaccination so we can get back to normal.Last edited by MultiVerse; 08-17-2021 at 02:24 PM.
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08-17-2021, 12:49 PM #9319glocal
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So what vaccine did everyone in Israel get?
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08-17-2021, 12:53 PM #9320
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08-17-2021, 12:54 PM #9321
Pfizer.
One of the reasons why Israeli numbers are causing so much alarm is because nearly all older people are vaccinated (>90% of residents >50yr) while the vast majority of unvaccinated are younger people. So if the calculations use averages in the denominator instead of vaccination rates by age groups then the numbers appear worse when vaccination rates are high.
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08-17-2021, 12:54 PM #9322
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08-17-2021, 12:56 PM #9323
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08-17-2021, 12:57 PM #9324
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08-17-2021, 12:58 PM #9325“When you see something that is not right, not just, not fair, you have a moral obligation to say something. To do something." Rep. John Lewis
Kindness is a bridge between all people
Dunkin’ Donuts Worker Dances With Customer Who Has Autism
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