Page 524 of 929 FirstFirst ... 519 520 521 522 523 524 525 526 527 528 529 ... LastLast
Results 13,076 to 13,100 of 23206
  1. #13076
    Join Date
    Dec 2005
    Posts
    11,096
    The mRNA volume in the Moderna shot is higher than pfizer I think. So while they both offer protection it appears that moderna’s is more robust over time

    Smarter people can chime in and correct me/post actual stats re:breakthroughs

  2. #13077
    Join Date
    Dec 2010
    Location
    Last Best City in the Last Best Place
    Posts
    7,237
    Quote Originally Posted by The SnowShow View Post
    A family at school all got COVID right before school started, except for the dad. The mom had the Pfizer shot and he had the Moderna. The two kids were unvaccinated.
    I’ve been wondering if there’s data out there about which shot had more breakthrough cases. Been interested that he didn’t come down with CV even though the rest of them did.
    Mom probably spends more time in the car with the kids.

  3. #13078
    Join Date
    Jan 2009
    Location
    Squaw valley
    Posts
    4,637
    Quote Originally Posted by old_newguy View Post
    Where are they going to take their skill set where they aren’t subject to the vaccine requirement?
    Exactly

    Sent from my Redmi Note 8 Pro using Tapatalk

  4. #13079
    Join Date
    Mar 2012
    Location
    The Bull City
    Posts
    14,003
    Quote Originally Posted by yeahman View Post
    I don't get "mandatory OT." What are they going to do, fire you when they're already understaffed? Doubt it.
    I've been places where they absolutely did that then just made everyone else work MORE overtime. It was working retail during the holiday season. Ya, a RN or PA has more options.. but bailing on your department in crisis isn't a good look on your resume when looking for a new gig..
    Go that way really REALLY fast. If something gets in your way, TURN!

  5. #13080
    Join Date
    Dec 2009
    Location
    ECO
    Posts
    5,805
    Vail Resorts requiring vax for all employees across all resorts and any guests for indoor dining. No masks in the lift line at present other than Whistler. I don’t know if that is going to help staffing issues.

  6. #13081
    Join Date
    Nov 2005
    Posts
    8,303
    Quote Originally Posted by The SnowShow View Post
    A family at school all got COVID right before school started, except for the dad. The mom had the Pfizer shot and he had the Moderna. The two kids were unvaccinated.
    I’ve been wondering if there’s data out there about which shot had more breakthrough cases. Been interested that he didn’t come down with CV even though the rest of them did.
    How long ago might also matter? Recently posted pre-print showed much better protection from modeRNA over time/against delta.

  7. #13082
    Join Date
    Sep 2001
    Location
    Before
    Posts
    27,877
    Quote Originally Posted by bennymac View Post
    The mRNA volume in the Moderna shot is higher than pfizer I think. So while they both offer protection it appears that moderna’s is more robust over time

    Smarter people can chime in and correct me/post actual stats re:breakthroughs
    Moderna had higher concentration than Pfizer.
    Merde De Glace On the Freak When Ski
    >>>200 cm Black Bamboo Sidewalled DPS Lotus 120 : Best Skis Ever <<<

  8. #13083
    Join Date
    Nov 2008
    Posts
    9,825
    Quote Originally Posted by Buster Highmen View Post
    Moderna had higher concentration than Pfizer.
    Yep; The numbers I saw made it sound like Moderna has 3X the load, which seems a little ....unusual?

    If a little is good, a lot must be AWSOME!! Works in not so many ways.

  9. #13084
    Join Date
    Dec 2005
    Posts
    11,096
    Quote Originally Posted by Buster Highmen View Post
    Moderna had higher concentration than Pfizer.
    Thanks for the correction

  10. #13085
    Join Date
    Dec 2010
    Location
    Last Best City in the Last Best Place
    Posts
    7,237
    Quote Originally Posted by SumJongGuy View Post
    I've been places where they absolutely did that then just made everyone else work MORE overtime. It was working retail during the holiday season. Ya, a RN or PA has more options.. but bailing on your department in crisis isn't a good look on your resume when looking for a new gig..
    Fuck those places then. Every job I've ever worked, they needed me more than I needed them, and no way would I let them fuck up my life like that. Healthcare workers can write their own ticket these days, they are so much in demand.

    Obviously it has more to do with their devotion to caring for people, even assholes, and I get that, but ultimately I think it's doing more harm than good to burn these people out and drive them out of the profession. I'd rather see anti-vaxxers turned away at the door to self-care at home. I know, I know, not going to happen.

    What pisses me off more than anything are stories like was in our paper a few days ago about how the anti vaxxers and their stupid family members are treating HC workers like shit even as they work to keep their ignorant asses alive. Those fucks need a bat to the face.

  11. #13086
    Join Date
    Jan 2010
    Location
    In the swamp
    Posts
    11,102

    To Vaccinate or Not---The Rat Flu Odyssey Continues

    Quote Originally Posted by jono View Post
    How long ago might also matter? Recently posted pre-print showed much better protection from modeRNA over time/against delta.
    They were sick about 3 weeks ago.

    At 3x the load, it must be awesome vs Pfizer?

  12. #13087
    Join Date
    Nov 2008
    Location
    Edge of the Great Basin
    Posts
    5,508
    Another possibility is the time between doses. As prescribed Pfizer is 3 weeks while Moderna is 4.

    The first vaccine dose, the prime dose, activates naive T cells as well as B cells. The properties of those critical T cells change over time after priming. The boost is then meant to stimulate or train the primary memory B and T cells creating a more potent immune response. If the first vaccine injections are too close in time to each other then the second dose acts as if its another primary dose rather than a boost.

    Dosage vs time matters because studies indicate a half-dose of the Moderna is just as effective as a full dose and even a quarter dose is nearly as effective. If those results hold up then lower doses could mean fewer side effects for the same results. And a delayed dosing interval could lead to an even better response.

  13. #13088
    Join Date
    Jul 2005
    Location
    Moose, Iowa
    Posts
    7,908
    I don't have the studies in front of me but Moderna's efficacy has barely dropped, Pfizer has dropped from 90ish to 80ish more.

    Combination of higher dosing with Moderna and the 30 day interval for the second dose probably elicits a bigger immune response.

    A 3rd dose months after dose 2 will probably put things back in balance.

    The studies are based on not enough data so other variables could be at play like shot demographics and exposure risks.

    Edit...multi beat me to it. He actually knows. I'm just a Twitter mirror.

  14. #13089
    Join Date
    Nov 2008
    Location
    Edge of the Great Basin
    Posts
    5,508
    ^ FWIW, real world UK data shows time makes a big difference. People with longer time intervals between doses had better results. The second dose or boost matters even more compared with people who only got a single dose. Even the time immediately after either the first second dose makes a big difference: people infected within three weeks of a dose experienced half the vaccine effectiveness as those three or more weeks out.

  15. #13090
    Join Date
    Jan 2008
    Location
    Big Sky/Moonlight Basin
    Posts
    14,366
    So with 2 Phizers in me, should I go 2+1 Moderna, or 3 Phizers ?


    Sent from my iPad using TGR Forums
    "Zee damn fat skis are ruining zee piste !" -Oscar Schevlin

    "Hike up your skirt and grow a dick you fucking crybaby" -what Bunion said to Harry at the top of The Headwaters

  16. #13091
    Join Date
    Nov 2008
    Location
    Edge of the Great Basin
    Posts
    5,508
    I don't think it matters, but at this point there's not much data on boosters to answer your question. We do know mix and match is fine and might even be better but Pfizer and Moderna are so similar in how they work a lot of people think they're effectively the same in terms of immune response. There is evidence showing either AZ or J&J followed by an mRNA shot offers even better protection but not the other way around so that doesn't apply to your situation.


    Totally unrelated is the unanswered question of whether single dose J&J folks should get a booster... I think a second mRNA boost makes a lot sense.

  17. #13092
    Join Date
    Mar 2006
    Posts
    19,804
    The booster #3 feels like #1 since it’s 5 months post #2. Hoping good to go tomorrow.

  18. #13093
    Join Date
    Aug 2006
    Posts
    8,938
    Quote Originally Posted by PB View Post
    Yep; The numbers I saw made it sound like Moderna has 3X the load, which seems a little ....unusual?

    If a little is good, a lot must be AWSOME!! Works in not so many ways.
    It takes dynamite to get me up
    Too much of everything is just enough

  19. #13094
    Join Date
    Sep 2001
    Location
    Before
    Posts
    27,877
    I can't find it, but somewhere there's an article about Pfizer management deciding to release a lower concentration vax in hopes of minimizing reactions and encouraging more people to get the poke.

    Being a geezer, I'm waiting for a booster until January.
    Merde De Glace On the Freak When Ski
    >>>200 cm Black Bamboo Sidewalled DPS Lotus 120 : Best Skis Ever <<<

  20. #13095
    Join Date
    Oct 2003
    Location
    Near Perimetr.
    Posts
    3,857
    Quote Originally Posted by MultiVerse View Post
    Another possibility is the time between doses. As prescribed Pfizer is 3 weeks while Moderna is 4.
    .
    Interesting to see how things pan out here; we had a 8-10 week interval between the doses due to gov going the route of getting everyone vaxxed asap.
    3rd rnd for immunocompromised has already started and if applicable, will be given later on for the rest of the population.
    Interesting to see if the "Mix-Tape" approach will gain traction...

    The floggings will continue until morale improves.

  21. #13096
    Join Date
    Jan 2007
    Location
    Upstate
    Posts
    9,656
    Yeah, so maybe pay your hospital staff a little more. You had to be blind not to see this coming from a mile away. Makes me want to own a construction company for the upcoming "expansion."

    https://www.axios.com/newsletters/ax...25ad8c02f.html

  22. #13097
    Join Date
    Oct 2003
    Location
    9,300ft
    Posts
    21,921
    Quote Originally Posted by wkd-rdr View Post
    Had a coworker die in the ER here. Everyone knew her, code went on for 2 hours... Two hours too many, because everyone knew her and couldn't quit. Awful shit.
    Very young, very unvaxxed.
    I feel ya, same thing happened a few weeks back, it's rough
    Quote Originally Posted by blurred
    skiing is hiking all day so that you can ski on shitty gear for 5 minutes.

  23. #13098
    Join Date
    Oct 2003
    Location
    Aspen
    Posts
    9,396
    Quote Originally Posted by The SnowShow View Post
    A family at school all got COVID right before school started, except for the dad. The mom had the Pfizer shot and he had the Moderna. The two kids were unvaccinated.
    I’ve been wondering if there’s data out there about which shot had more breakthrough cases. Been interested that he didn’t come down with CV even though the rest of them did.
    Colorado is tracking this. https://public.tableau.com/views/Vac...device=desktop

    Pfizer is at 100 per 100k. Moderna is at 75 per 100k and J&J is at 150 per 100k.

  24. #13099
    Join Date
    Mar 2012
    Location
    The Bull City
    Posts
    14,003
    Vaccinated people sitting by listening to the pretzel logic of the science deniers..

    Click image for larger version. 

Name:	princess-bride-movie-screencaps.com-3932.jpg 
Views:	71 
Size:	436.5 KB 
ID:	386130
    Go that way really REALLY fast. If something gets in your way, TURN!

  25. #13100
    Join Date
    Sep 2005
    Location
    Fresh Lake City
    Posts
    4,573
    It's getting real down under

    Sent from my Pixel 4a using Tapatalk

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •