Results 11,851 to 11,875 of 23206
-
09-09-2021, 05:59 PM #11851
Transmission is a function of viral load over time. Shortening the period of high viral load shortens transmission window. If you are still not following, a shorter transmission window means less transmission.
https://www.medrxiv.org/content/10.1...1262158v1.full
Virological characteristics of SARS-CoV-2 vaccine breakthrough infections in health care workers
Methods We analyzed the virological characteristics of 161 vaccine breakthrough infections in a population of 24,706 vaccinated healthcare workers (HCWs), using RT-PCR and virus culture.
Results The delta variant (B.1.617.2) was identified in the majority of cases. Despite similar Ct-values, we demonstrate lower probability of infectious virus detection in respiratory samples of vaccinated HCWs with breakthrough infections compared to unvaccinated HCWs with primary SARS-CoV-2 infections. Nevertheless, infectious virus was found in 68.6% of breakthrough infections and Ct-values decreased throughout the first 3 days of illness.
Conclusions We conclude that rare vaccine breakthrough infections occur, but infectious virus shedding is reduced in these cases.
https://www.medrxiv.org/content/10.1...%20individuals
Viral dynamics of SARS-CoV-2 variants in vaccinated and unvaccinated individuals
Background The alpha and delta SARS-CoV-2 variants have been responsible for major recent waves of COVID-19 despite increasing vaccination rates. The reasons for the increased transmissibility of these variants and for the reduced transmissibility of vaccine breakthrough infections are unclear.
Methods We quantified the course of viral proliferation and clearance for 173 individuals with acute SARS-CoV-2 infections using longitudinal quantitative RT-PCR tests conducted using anterior nares/oropharyngeal samples (n = 199,941) as part of the National Basketball Association’s (NBA) occupational health program between November 28th, 2020, and August 11th, 2021. We measured the duration of viral proliferation and clearance and the peak viral concentration separately for individuals infected with alpha, delta, and non-variants of interest/variants of concern (non-VOI/VOC), and for vaccinated and unvaccinated individuals.
Results
The mean viral trajectories of alpha and delta infections resembled those of non-VOI/VOC infections. Vaccine breakthrough infections exhibited similar proliferation dynamics as infections in unvaccinated individuals (mean peak Ct: 20.5, 95% credible interval [19.0, 21.0] vs. 20.7 [19.8, 20.2], and mean proliferation time 3.2 days [2.5, 4.0] vs. 3.5 days [3.0, 4.0]); however, vaccinated individuals exhibited faster clearance (mean clearance time: 5.5 days [4.6, 6.6] vs. 7.5 days [6.8, 8.2]).
Conclusions Alpha, delta, and non-VOI/VOC infections feature similar viral trajectories. Acute infections in vaccinated and unvaccinated people feature similar proliferation and peak Ct, but vaccinated individuals cleared the infection more quickly. Viral concentrations do not fully explain the differences in infectiousness between SARS-CoV-2 variants, and mitigation measures are needed to limit transmission from vaccinated individuals.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423226/
Longitudinal analysis of SARS-CoV-2 vaccine breakthrough infections reveal limited infectious virus shedding and restricted tissue distribution
ABSTRACT
The global effort to vaccinate people against SARS-CoV-2 in the midst of an ongoing pandemic has raised questions about the nature of vaccine breakthrough infections and the potential for vaccinated individuals to transmit the virus. These questions have become even more urgent as new variants of concern with enhanced transmissibility, such as Delta, continue to emerge. To shed light on how vaccine breakthrough infections compare with infections in immunologically naive individuals, we examined viral dynamics and infectious virus shedding through daily longitudinal sampling in a small cohort of adults infected with SARS-CoV-2 at varying stages of vaccination. The durations of both infectious virus shedding and symptoms were significantly reduced in vaccinated individuals compared with unvaccinated individuals. We also observed that breakthrough infections are associated with strong tissue compartmentalization and are only detectable in saliva in some cases. These data indicate that vaccination shortens the duration of time of high transmission potential, minimizes symptom duration, and may restrict tissue dissemination.
Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine-breakthrough infections: a multi-center cohort study
https://www.medrxiv.org/content/10.1....28.21261295v1
Methods We conducted a multi-centre retrospective cohort study of patients in Singapore who had received a licensed mRNA vaccine and been admitted to hospital with B.1.617.2 SARS-CoV-2 infection. We compared the clinical features, virological and serological kinetics (anti-nucleocapsid, anti-spike and surrogate virus neutralization titres) between fully vaccinated and unvaccinated individuals.
Results
Of 218 individuals with B.1.617.2 infection, 84 had received a mRNA vaccine of which 71 were fully vaccinated, 130 were unvaccinated and 4 received a non-mRNA. Despite significantly older age in the vaccine breakthrough group, the odds of severe COVID-19 requiring oxygen supplementation was significantly lower following vaccination (adjusted odds ratio 0.07 95%CI: 0.015-0.335, p=0.001). PCR cycle threshold (Ct) values were similar between both vaccinated and unvaccinated groups at diagnosis, but viral loads decreased faster in vaccinated individuals. Early, robust boosting of anti-spike protein antibodies was observed in vaccinated patients, however, these titers were significantly lower against B.1.617.2 as compared with the wildtype vaccine strain.
.....
4 studies from 4 different countries showing less Delta transmission in vaccinated despite similar high levels of virus at the time of peak viremia due to more rapid clearance in vaccinated individuals.
This is where the root of "may" and "will likely" come from, not from a hypothetical.Move upside and let the man go through...
-
09-09-2021, 06:11 PM #11852
Thanks Mofro for saying the same fking thing over and over again so the kids in the back of the class MIGHT get it. I un blocked skidog as I'm on pins and needles waiting for his reply.
A few people feel the rain. Most people just get wet.
-
09-09-2021, 06:11 PM #11853
-
09-09-2021, 06:13 PM #11854Registered User
- Join Date
- Oct 2010
- Posts
- 1,744
Mofro, can't thank you enough for spelling all of this out.
-
09-09-2021, 06:14 PM #11855
This is exactly where I don't understand people like Skidog (no offense) and his point of view. "will likely" seems a lot better than doing nothing to me, which I think is where his argument logically concludes. Skidog, can you agree that vaccination "will likely" reduce transmission and therefore get fucking vaccinated (again, not that you aren't)!
Again, I don't get the mentality of someone like mtuhockey33...healthcare professionals, infectious disease experts, etc. are pleading with you to get vaccinated and you see something like the hospital ICUs overrun with antivaxxing people as some grand conspiracy by infectious disease experts/pharmaceutical companies/doctors/CDC/FDA/US DOD/etc. etc. etc. to trick you into getting some harmful vaccine? Just look at the statistics of who ends up with serious complications to COVID and you'll see it's around 99% unvaxed people....WHAT THE FUCK IS WRONG WITH YOU? GET VACCINATED ASSHOLE.Damn shame, throwing away a perfectly good white boy like that
-
09-09-2021, 06:35 PM #11856
His original statement wasn't wrong, but it was misleading as it is incomplete. We are seeing similar high levels of virus in both vaxxed and unvaxxed, but with different outcomes for severity of symptoms, length of symptoms, and potential for transmission.
Local data here tracking infection, hospitalization, and death rates in Age-adjusted population:
https://kingcounty.gov/depts/health/...-outcomes.aspx
Really it tells the same story that's playing out almost everywhere. Vaccination remains the safest way to achieve some immunity and lessen the impact of Covid if/when an exposure happens.Move upside and let the man go through...
-
09-09-2021, 06:36 PM #11857
-
09-09-2021, 06:48 PM #11858Banned
- Join Date
- Oct 2012
- Posts
- 10,525
-
09-09-2021, 06:49 PM #11859
-
09-09-2021, 06:49 PM #11860Banned
- Join Date
- Oct 2012
- Posts
- 10,525
-
09-09-2021, 06:50 PM #11861
IMO, he was wrong to infer that there was a reason to doubt the vaccine effectiveness because it is not absolute. I got what you and science were saying days ago. And I'm not that smart.
A few people feel the rain. Most people just get wet.
-
09-09-2021, 06:54 PM #11862
-
09-09-2021, 07:01 PM #11863
About fucking time! Too bad it had to get this bad again in order for Biden to do this. I’m sure that behind the scenes plenty of chamber of commerce people were hoping he’d do this. We get vaccination levels were they need to be and COVID-19 will be just the flu. IE life goes along pretty normally. The party of so called personal responsibility has proven that its voters have zero sense of responsibility to themselves, their family and lastly their fellow countrymen and hence the country. Bunch of fake fucking patriots and idiots to top.
Sent from my iPad using TGR Forums
-
09-09-2021, 07:06 PM #11864
-
09-09-2021, 07:11 PM #11865
Ya like the big donors to DeSantis laughing all the way to the bank as he fills the hospitals with Regeneron Monoclonal Anitbody Treatment customers?
AP: Top Donor Of Gov. Ron DeSantis Is Regeneron InvestorGo that way really REALLY fast. If something gets in your way, TURN!
-
09-09-2021, 08:54 PM #11866
-
09-09-2021, 09:05 PM #11867Registered User
- Join Date
- Apr 2006
- Location
- SF & the Ho
- Posts
- 9,296
Def gonna post that on my friend’s page that is currently ranting about fauci being a criminal lol
-
09-09-2021, 10:03 PM #11868
-
09-09-2021, 10:37 PM #11869
-
09-10-2021, 03:32 AM #11870
You really want evil Germans to meddle in foreign affairs?
And Russia? I think I'll take any of the EU countries first.
Oh wait. The eu has actually started helping worldwide and has never stopped vaccines from being exported despite the early shortage. Unlike other countries.
BTW. You know that the term Oceania does not include Latin (or any) America. But it's nice that you want America to save the billion Polynesians and new Zealanders.It's a war of the mind and we're armed to the teeth.
-
09-10-2021, 04:15 AM #11871Banned
- Join Date
- May 2007
- Location
- Sandy, Utah
- Posts
- 14,410
Guess you'd better inform the CDC cause the link I posted was updated a out a week ago.
Sent from my Pixel 4a (5G) using TGR Forums mobile app
-
09-10-2021, 04:22 AM #11872Banned
- Join Date
- May 2007
- Location
- Sandy, Utah
- Posts
- 14,410
Ok great. I took my info from the CDC site, you guys use it when it suits you and when it doesn't you'll find some other study to refute it. The CDC says those key words I highlighted. Zero definitive answers. Again updated 08/26/2021.
If you think everyday people will search out these obscure studies that they mostly can't understand, well you're crazy. If Delta viral load isn't close to the same vaxxed or unvaxxed the CDC site should state as much clearly. It doesn't say that's
Sent from my Pixel 4a (5G) using TGR Forums mobile app
-
09-10-2021, 04:24 AM #11873Banned
- Join Date
- May 2007
- Location
- Sandy, Utah
- Posts
- 14,410
And I agree 100%, get a vax. Doesn't change the fact that a lot is still up in the air with variants and full vax effectiveness. Which is all I said originally.
Sent from my Pixel 4a (5G) using TGR Forums mobile app
-
09-10-2021, 04:28 AM #11874Banned
- Join Date
- May 2007
- Location
- Sandy, Utah
- Posts
- 14,410
Where did I state I doubt the vaccine effectiveness? It's keeping those vaxxed mostly safe from Delta, but those vaxxed can still transmit viral loads, even without symptoms. The vax is pretty effective.
Sent from my Pixel 4a (5G) using TGR Forums mobile app
-
09-10-2021, 05:48 AM #11875
Bookmarks