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01-19-2022, 09:21 PM #19976Registered User
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01-19-2022, 09:36 PM #19977
Farmer is majorly immunocompromised, is >65 and has a risk factor, or he has two risk factors for severe COVID.
Either that or the hospital needs to fucking share their Sotrovimab with the other hospitals that are out of mAbs despite more restrictive inclusion criteria.Originally Posted by blurred
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01-19-2022, 09:43 PM #19978"fuck off you asshat gaper shit for brains fucktard wanker." - Jesus Christ
"She was tossing her bean salad with the vigor of a Drunken Pop princess so I walked out of the corner and said.... "need a hand?"" - Odin
"everybody's got their hooks into you, fuck em....forge on motherfuckers, drag all those bitches across the goal line with you." - (not so) ill-advised strategy
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01-19-2022, 09:58 PM #19979Registered User
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01-19-2022, 10:05 PM #19980Registered User
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01-19-2022, 10:33 PM #19981
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01-19-2022, 10:48 PM #19982Registered User
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01-19-2022, 10:59 PM #19983
Emergency room and hospital sure. Other services still happen.
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01-19-2022, 11:27 PM #19984
You're getting it. The first people don't need convincing, just a chance to volunteer. Phase I for safety and verify the dosing and move on. The volunteers become the proof anyway. (And they should be paid for that service, but that's another topic.)
The airplane analogy is a bit like fitting a substitute component: some stuff needs to be tested, but a lot can be skipped by analyzing what changed (or didn't). One difference in civilian aircraft is there is no added risk allowed--there's no way to justify that, so a new part has to be as safe or safer.
This is more like military aircraft where you can often trade some reliability for performance and be net safer--if you're being shot at, getting away faster is safer. There's a risk to not improving.A woman came up to me and said "I'd like to poison your mind
with wrong ideas that appeal to you, though I am not unkind."
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01-19-2022, 11:32 PM #19985
Small town. Only place to get a test is the hospital. Testing was drive through in the parking lot across the street. Regeneron treatment was in a pop up building in the parking garage.
I had symptoms, but nothing hospital worthy. Oxygen was at 97% when they took vitals during the treatment this morning.
Sent from my motorola one 5G ace using TapatalkOriginally Posted by Smoke
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01-19-2022, 11:41 PM #19986
Theoretical problem is that if changing the mRNA vaccine to address a new strain's spike protein (or functional equivalent that serves to allow viral entry into the cell), there's no guarantee the translated protein will fold to the proper 3D morphology that serves as a useful epitope for the immune system to act on.
Question mofro might be able to address is what are the odds of generating an epitope that leads to negative consequences?
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01-20-2022, 12:15 AM #19987Rod9301
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01-20-2022, 01:05 AM #19988
Would this be more of a problem for SARS-CoV2 than flu?
Along similar lines, if producing an omicron-specific vaccine, is there a reason it couldn't be mixed with one for original or delta? Curious about the implications for Corbevax, for example: if they produce 100M doses/month and then come out with a new one, could the "old" doses be mixed with a newer version, or anything similar?
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01-20-2022, 04:37 AM #19989
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01-20-2022, 07:46 AM #19990
Psst. Science was quickly able to determine the structure of omicron, and of course the virus also uses this same RNA sequence to produce its folded spike trimer, inside the human cell.
We don't have an issue with proper protein folding based on size exclusion chromatography and retention of Mab binding for any of the spikes we have made- now including omicron.
But remember, in order for that mRNA vaccine to work, we actually need to form a Spike trimer on the outside of the cell the mRNA is delivered to, via transit the ER and golgi apparatus. Unfolded and misfolded proteins won't make it through to get placed on the cell surface and are targeted to degradation pathways.
Ie, this is a non-issue.Move upside and let the man go through...
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01-20-2022, 07:56 AM #19991
Covid.....political asshattery for the modern, albeit aged, TGR collective.
FWIW, I work in a community that very much supports Trump, and most of the population at highest risk (over 65) is vaccinated. They understand the risk. I can't cite specific percentages, but I'm surprised at how many patients tell me they had their booster, and I assumed they had not been vaccinated.
Continually generalizing entire demographics does nothing to further vaccination efforts. Certainly increases push back and makes my job infinitely more difficult, and perhaps cost me $$ as some of my income is based on quality measures that revolve around vaccinations.Last edited by Trackhead; 01-20-2022 at 08:23 AM.
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01-20-2022, 08:32 AM #19992FWIW, I work in a community that very much supports Trump, and most of the population at highest risk (over 65) is vaccinated. They understand the risk. I can't cite specific percentages, but I'm surprised at how many patients tell me they had their booster, and I assumed they had not been vaccinated.I have been in this State for 30 years and I am willing to admit that I am part of the problem.
"Happiest years of my life were earning < $8.00 and hour, collecting unemployment every spring and fall, no car, no debt and no responsibilities. 1984-1990 Park City UT"
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01-20-2022, 08:40 AM #19993
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01-20-2022, 08:44 AM #19994
False
https://www.politifact.com/factcheck...eveloping-imm/
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01-20-2022, 08:52 AM #19995
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01-20-2022, 09:00 AM #19996
If you were hospital-worthy or had low oxygen due to COVID-19, it would have excluded you from getting the treatment. Hopefully you will not get any worse and recover quickly!
Are you sure they gave you Regeneron and not Sotrovimab? We stopped giving Regeneron over a month ago because it doesn't work against Omicron. They stopped shipping Regeneron nationally 4 weeks ago.
Everything is Omicron.Originally Posted by blurred
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01-20-2022, 09:24 AM #19997
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01-20-2022, 09:34 AM #19998
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01-20-2022, 09:45 AM #19999
Full Blown AIDS!!!!
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01-20-2022, 09:49 AM #20000Registered User
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