Page 847 of 1673 FirstFirst ... 842 843 844 845 846 847 848 849 850 851 852 ... LastLast
Results 21,151 to 21,175 of 41810
  1. #21151
    Join Date
    May 2014
    Location
    Santiago Chile
    Posts
    1,719
    Mobility would seem to be a key factor in virus spread. In Santiago, one of the most "contagious" cities in the world right now, after 5 weeks of lockdown, mobility has only dropped 35%. That varies from only 24% in poorer districts, to 50% in richer ones, when it should be 60-70%.

    Chile now has almost double the number of confirmed cases per million of the USA, and Santiago triple. Positives represent 1.3% of the country population, and 2.5% in Santiago. USA is 0.8% with almost double the rate of testing.

    https://santiagotimes.cl/2020/06/23/...rosses-250000/

    "Carabineros reported the detention of 17,321 citizens who did not comply with the quarantine measures, between June 15 and 21.
    Of the total number of people who were detained, 12,010 (69.3%) were for crimes against public health, 6,962 for traveling outside curfew hours, 4,805 for curfew hours and 243 for other crimes against public health. Among those captured, the profile corresponds mainly to people between 18 and 30 years of age, mostly men."

    This is just the ones they caught. Many thousands every day get "official" permits for 2 hours up to 2 weeks, maliciously, to visit friends/family, run non-essential errands, ride bikes, etc. My son, a neurologist, has to put up frequent no-shows, which would be false medical permits.

    Here is a photo of the Santiago central market, where we used to love shopping for fresh fruit and vegetables, under quarantine, where only "wholesalers" with permits are allowed.

    Click image for larger version. 

Name:	IMG_9292.jpg 
Views:	103 
Size:	937.3 KB 
ID:	332649

    And more from the poorer districts

    Click image for larger version. 

Name:	IMG_9293.jpg 
Views:	104 
Size:	868.4 KB 
ID:	332650

  2. #21152
    Join Date
    Aug 2006
    Posts
    8,963
    Quote Originally Posted by smmokan View Post
    California has money? Who knew.
    The states control the Federal (FEMA) $$, too.

  3. #21153
    Join Date
    Jan 2005
    Location
    cb, co
    Posts
    5,035
    Quote Originally Posted by bodywhomper View Post
    California looks like it’ll flex it $$ power with mask wearing, threatening to not provide COVID emergency $$ to cities and counties that cannot demonstrate compliance the the mask wearing ordered by the governor.
    In other words, the exact opposite approach that Nebraska is taking. (I linked ? pages ago that the NE governor would withhold COVID $ from counties that imposed mask wearing)

  4. #21154
    Join Date
    Aug 2006
    Location
    Ogden
    Posts
    937
    Quote Originally Posted by KQ View Post
    Lots of wine tourist in DT W2 today and it's only Thursday.
    i bagged my Grande Ronde and Wallowas trip because skipping W2 wine would have been too hard. didn’t want to risk giving the Seattle covfefe back to your antifa winetasting tourists.

    so there’s that.
    bumps are for poor people

  5. #21155
    Join Date
    Aug 2006
    Posts
    8,963
    Quote Originally Posted by goldenboy View Post
    In other words, the exact opposite approach that Nebraska is taking. (I linked ? pages ago that the NE governor would withhold COVID $ from counties that imposed mask wearing)
    Yeah. That’s crazy.

  6. #21156
    Join Date
    Oct 2004
    Location
    50 miles E of Paradise
    Posts
    15,566
    Quote Originally Posted by westoxified View Post
    i bagged my Grande Ronde and Wallowas trip because skipping W2 wine would have been too hard. didn’t want to risk giving the Seattle covfefe back to your antifa winetasting tourists.

    so there’s that.
    You could go to LaGrande, with the highest rate of Covid in OR, thanks to the cabrons at the Lighthouse Pentecostal Church,
    A story from a resident who got it from those pendejas. Fucked up on so many levels.
    https://www.lagrandeobserver.com/cor...ce959242c.html

  7. #21157
    Join Date
    May 2002
    Posts
    33,440
    When antibodies are derived from plasma is that concentration the biggest factor in healing/immunity response? What effect would a direct blood transfusion from someone who, say, had detectable antibodies and the same blood type as a non-infected person who receives the transfusion, have with regard to forming an immunity?

  8. #21158
    Join Date
    Aug 2013
    Location
    shadow of HS butte
    Posts
    6,397
    Our response to the COVID has been very similar to how we complete large infrastructure projects in this country.

    Instead of telling people to suck it up and deal with a full closure for a couple weeks/months, we dick around and draw out the process for years. Imagine if in March we locked everything down, hard, for 2 months. Would that have been less impactful than dealing with it for the next 8 months, year, 2 years? Somewhat of a utopian view, just something that crossed my mind.

    Think the reality is this isn't going away until it runs its course. Even if the country was locked down to the point where all current cases were no longer contagious, how would you prevent from coming in from other countries?

  9. #21159
    Join Date
    Dec 2003
    Location
    Seattle
    Posts
    33,546
    Quote Originally Posted by splat View Post
    When antibodies are derived from plasma is that concentration the biggest factor in healing/immunity response? What effect would a direct blood transfusion from someone who, say, had detectable antibodies and the same blood type as a non-infected person who receives the transfusion, have with regard to forming an immunity?
    I bet someone has already thought of that.

    https://www.hematology.org/covid-19/...lescent-plasma
    Quote Originally Posted by Downbound Train View Post
    And there will come a day when our ancestors look back...........

  10. #21160
    Join Date
    Jan 2010
    Location
    In the swamp
    Posts
    11,124

    Fear and Loathing, a Rat Flu Odyssey

    Quote Originally Posted by east or bust View Post
    Our response to the COVID has been very similar to how we complete large infrastructure projects in this country.

    Instead of telling people to suck it up and deal with a full closure for a couple weeks/months, we dick around and draw out the process for years. Imagine if in March we locked everything down, hard, for 2 months. Would that have been less impactful than dealing with it for the next 8 months, year, 2 years? Somewhat of a utopian view, just something that crossed my mind.

    Think the reality is this isn't going away until it runs its course. Even if the country was locked down to the point where all current cases were no longer contagious, how would you prevent from coming in from other countries?
    Good point. During our “lockdown”, I wondered about whether a real Spain or Italian lockdown would have been more impactful in the long run. Would the economy be any worse off if we had done that then?

    A full travel ban would accomplish keeping it out but that’s unrealistic.

  11. #21161
    Join Date
    Jan 2005
    Location
    Keep Tacoma Feared
    Posts
    5,266
    Casey E, appreciate the Chile updates. That is interesting.

  12. #21162
    Join Date
    Nov 2002
    Location
    EWA
    Posts
    22,004
    Quote Originally Posted by westoxified View Post
    i bagged my Grande Ronde and Wallowas trip because skipping W2 wine would have been too hard. didn’t want to risk giving the Seattle covfefe back to your antifa winetasting tourists.

    so there’s that.

    You can still come - we're open, you've just gotta wear a mask:

    When you see something that is not right, not just, not fair, you have a moral obligation to say something. To do something." Rep. John Lewis


    Kindness is a bridge between all people

    Dunkin’ Donuts Worker Dances With Customer Who Has Autism

  13. #21163
    Join Date
    Nov 2002
    Location
    EWA
    Posts
    22,004
    When you see something that is not right, not just, not fair, you have a moral obligation to say something. To do something." Rep. John Lewis


    Kindness is a bridge between all people

    Dunkin’ Donuts Worker Dances With Customer Who Has Autism

  14. #21164
    Join Date
    Oct 2003
    Location
    Redwood City
    Posts
    1,761
    Regarding how antibodies/immunity works: the way I always explain it is think of when your body gets a new infection, it has to pick a lock on each virus to kill it. At first, it doesn't know the combination needed to open the lock. So the first thing your immune system does is go into a mode that tries out millions of combinations at once. This is called somatic hypermutation. Then, when it fi ds the correct combination, a signal is sent out and your body starts making millions of copies of that antibody with the correct combination. This is called clonal expansion. Those combinations are on two things: BCells which produce antibodies that bind to the virus and hopefully block it from entering cells, and TCells which find already infected cells and kills them so they can't make more copies of the virus. So while you are clearing the infection, you have lots of antibodies floating around. After it is cleared, your body keeps a memory of the combination that worked at a much lower level so if it sees the virus again, it can skip the lock picking (somatic hypermutation) and go right to clonal expansion.

  15. #21165
    Join Date
    Jan 2008
    Location
    truckee
    Posts
    23,111
    Quote Originally Posted by east or bust View Post
    Our response to the COVID has been very similar to how we complete large infrastructure projects in this country.

    Instead of telling people to suck it up and deal with a full closure for a couple weeks/months, we dick around and draw out the process for years. Imagine if in March we locked everything down, hard, for 2 months. Would that have been less impactful than dealing with it for the next 8 months, year, 2 years? Somewhat of a utopian view, just something that crossed my mind.

    Think the reality is this isn't going away until it runs its course. Even if the country was locked down to the point where all current cases were no longer contagious, how would you prevent from coming in from other countries?
    It remains to be seen if countries who have appeared to control the virus will continue to do so. It's way to soon for us to know if they will spike or not. The strategy of locking things down tight is based on the assumption that there will be a vaccine. If there isn't a vaccine it is quite possible that the virus will slowly burn through the population until herd immunity is reached (if in fact recovered people are immune).

    We also don't know if there's anything seasonal about this virus and if it comes in waves is that biological on the part of the virus or behavioral on the part of populations.

  16. #21166
    Join Date
    Nov 2002
    Location
    EWA
    Posts
    22,004
    From the "this is nuts!" department:

    The Lewis county sheriff (EWA) in response to the governor's mask mandate grabbed a bullhorn and told people not to be sheep by wearing masks.

    I'm at a loss. Truly.
    When you see something that is not right, not just, not fair, you have a moral obligation to say something. To do something." Rep. John Lewis


    Kindness is a bridge between all people

    Dunkin’ Donuts Worker Dances With Customer Who Has Autism

  17. #21167
    Join Date
    Oct 2003
    Location
    Redwood City
    Posts
    1,761
    So a vaccine is of course a product that I'd designed to get your body to pick a lock that has the same or similar combination as the real virus. So when you get infected, you also get to skip somatic hypermutation. Even if the combination isn't exact, maybe it's like 8 of 10 numbers so your body can pick the lock faster. Also might be the case with cross reactivity of similar viruses. Neutralizing antibodies are not helping your 3know how to pick the lock but are just the products of clonal expansion. They will help you fight off a current infection but not help you remember the combination for next time.

  18. #21168
    Join Date
    Feb 2012
    Posts
    692
    Quote Originally Posted by LegoSkier View Post
    Regarding how antibodies/immunity works: the way I always explain it is think of when your body gets a new infection, it has to pick a lock on each virus to kill it. At first, it doesn't know the combination needed to open the lock. So the first thing your immune system does is go into a mode that tries out millions of combinations at once. This is called somatic hypermutation. Then, when it fi ds the correct combination, a signal is sent out and your body starts making millions of copies of that antibody with the correct combination. This is called clonal expansion. Those combinations are on two things: BCells which produce antibodies that bind to the virus and hopefully block it from entering cells, and TCells which find already infected cells and kills them so they can't make more copies of the virus. So while you are clearing the infection, you have lots of antibodies floating around. After it is cleared, your body keeps a memory of the combination that worked at a much lower level so if it sees the virus again, it can skip the lock picking (somatic hypermutation) and go right to clonal expansion.
    Thanks for that explanation. Why is it that there seems to be so much concern over the news that antibodies are no longer present in covid patients after only two months? Just general hype/fear mongering or are they supposed to hang around longer?

  19. #21169
    Join Date
    Feb 2009
    Location
    On Vacation for the Duration
    Posts
    14,373
    Quote Originally Posted by KQ View Post
    From the "this is nuts!" department:

    The Lewis county sheriff (EWA) in response to the governor's mask mandate grabbed a bullhorn and told people not to be sheep by wearing masks.

    I'm at a loss. Truly.
    He knows who elected him.
    A few people feel the rain. Most people just get wet.

  20. #21170
    Join Date
    Jan 2007
    Location
    Upstate
    Posts
    9,674
    Quote Originally Posted by splat View Post
    When antibodies are derived from plasma is that concentration the biggest factor in healing/immunity response? What effect would a direct blood transfusion from someone who, say, had detectable antibodies and the same blood type as a non-infected person who receives the transfusion, have with regard to forming an immunity?
    If you're asking whether convalescent plasma used to treat active infection creates immunity, the answer is "possibly" although this has yet to be demonstrated AFAIK. Plasma contains B-cells (in addition to the antibodies themselves) from the donor. If the donor has established a memory response (which as you've seen in the news is not a foregone conclusion for recovered patients), then those B-cells should take up residence and continue to make anti-viral antibodies. However, in the cases where plasma donation is thought to be effective, no one knows if the response is mediated by the antibodies in the plasma or the B-cells that produce more once there.

    Again, I'm not an immunologist.

  21. #21171
    Join Date
    Nov 2002
    Location
    EWA
    Posts
    22,004
    Quote Originally Posted by wooley12 View Post
    He knows who elected him.
    Correction: Lewis county is WWA but yeah... conservative.
    When you see something that is not right, not just, not fair, you have a moral obligation to say something. To do something." Rep. John Lewis


    Kindness is a bridge between all people

    Dunkin’ Donuts Worker Dances With Customer Who Has Autism

  22. #21172
    Join Date
    Feb 2012
    Posts
    10,904
    Quote Originally Posted by LegoSkier View Post
    Regarding how antibodies/immunity works: the way I always explain it is think of when your body gets a new infection, it has to pick a lock on each virus to kill it. At first, it doesn't know the combination needed to open the lock. So the first thing your immune system does is go into a mode that tries out millions of combinations at once. This is called somatic hypermutation. Then, when it fi ds the correct combination, a signal is sent out and your body starts making millions of copies of that antibody with the correct combination. This is called clonal expansion. Those combinations are on two things: BCells which produce antibodies that bind to the virus and hopefully block it from entering cells, and TCells which find already infected cells and kills them so they can't make more copies of the virus. So while you are clearing the infection, you have lots of antibodies floating around. After it is cleared, your body keeps a memory of the combination that worked at a much lower level so if it sees the virus again, it can skip the lock picking (somatic hypermutation) and go right to clonal expansion.
    Thanks, I enjoy the dumbed down explanations since I don’t come to TGR to think.

    Pretty cool stuff


    Sent from my iPhone using TGR Forums

  23. #21173
    Join Date
    Jan 2007
    Location
    Upstate
    Posts
    9,674
    Quote Originally Posted by dannynoonan View Post
    Thanks for that explanation. Why is it that there seems to be so much concern over the news that antibodies are no longer present in covid patients after only two months? Just general hype/fear mongering or are they supposed to hang around longer?
    Good vaccines develop long term memory (think years and years). The lack of circulating antibodies (even low level) is a red flag that you've lost memory and need a booster assuming a vaccine is available. If you've lost memory and can't be boosted then you're obviously not immune to a new infection and your body has to "pick the lock" again as Lego put it.

  24. #21174
    Join Date
    Dec 2010
    Location
    Last Best City in the Last Best Place
    Posts
    7,268
    Quote Originally Posted by altasnob View Post
    CDC says between 5 percent and 8 percent of Americans have been infected to date.The number of Americans who have been infected with the coronavirus is most likely about 10 times higher than the 2.3 million cases that have been reported.
    Does that 10X higher unreported infection rate mean the fatality rate is actually 1/10 what they thought it was?

  25. #21175
    Join Date
    Aug 2006
    Posts
    8,963
    Quote Originally Posted by old goat View Post
    We also don't know if there's anything seasonal about this virus and if it comes in waves is that biological on the part of the virus or behavioral on the part of populations.
    Wouldn’t the current observations that this virus is spreading in both hemispheres for 6 months be an indicator that seasonality isn’t much of a factor, except for people’s differing behaviors during the seasons...?

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •