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  1. #17326
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    Jul 2005
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    Moose, Iowa
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    6,314
    Lolz.

    Sent from my SM-G950U using Tapatalk

  2. #17327
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    Dec 2005
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    3,310
    Quote Originally Posted by wooley12 View Post
    18,000 views in two days. My nephew is a pro at creating mashups with some talent, but I may be biased.

    wow that was really well done

  3. #17328
    Join Date
    Jan 2010
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    Walpole NH
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    8,489
    We always had fish for dinner on Friday night, no meat ever, Lent or not. Catholicism is huge in Massachusetts.
    Do you like fish sticks?
    crab in my shoe mouth

  4. #17329
    Join Date
    Apr 2006
    Location
    SF & the Ho
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    6,239

    Fear and Loathing, a Rat Flu Odyssey

    Quote Originally Posted by Diamond Joe View Post
    How does an extra $2400 not BEGIN to give you enough to buy health insurance?

    "Premiums for individual coverage averaged $440 per month while premiums for family plans averaged $1,168 per month"
    https://www.ehealthinsurance.com/res...ithout-subsidy

    Seems to me that extra $2400 would not only begin to give them enough, it *would* give them, more than double the amount that they would need to enroll in an Obamacare insurance plan.
    Depends on how much they made already this year and how close they are to the subsidy cut off. If they are far below the acá subsidy, it’s entirely feasible they could get a plan for a $1 w the aca subsidy. Without the ACA subsidy, $2400 is useless. However, it probably would have been better/easier to just exclude the covid subsidy payment from Medicaid income calculations. Totally foreseeable and should not have been missed.

  5. #17330
    Join Date
    Nov 2005
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    3,673
    Quote Originally Posted by bennymac View Post
    Holee shit
    There's a thread for that. This isn't it.
    That one is accessible with a password you entered long ago.

  6. #17331
    Join Date
    Feb 2009
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    On Vacation for the Duration
    Posts
    12,445
    My nephew is a professional mashup artist. Freelance and looking for gigs
    Shameless plug
    A few people feel the rain. Most people just get wet.

  7. #17332
    Join Date
    Dec 2005
    Posts
    3,310
    Quote Originally Posted by jono View Post
    There's a thread for that. This isn't it.
    That one is accessible with a password you entered long ago.
    which is why I didn't get into the details of that troll's long history of being an incredible asshole

    and it's not really a password - it's just an "I agree" button that says you won't complain to the mods

    back to the European Rat Flu discussion!

  8. #17333
    Join Date
    Dec 2004
    Posts
    13,969
    Quote Originally Posted by uglymoney View Post
    Lolz.

    Sent from my SM-G950U using Tapatalk
    I feel sorry for her that she is sick and married to an asshole.
    Ooof!

  9. #17334
    Join Date
    May 2009
    Location
    inpdx
    Posts
    13,167
    what test is Trump getting multiple times each week to determine whether he's got the Corona? (for that matter Pence too)

    after hearing about the swap-up-the-nose one from a friend whose kid had to go to the hospital for a broken arm surgery, i'm sure Trump isn't sitting for that one even a second time...don't even consider multiple each week

  10. #17335
    Join Date
    Oct 2003
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    Switzerland
    Posts
    7,550
    Quote Originally Posted by bennymac View Post
    You guys spout shit with a sense of authority and conviction and then when your post gets criticized you respond with "well I'm not really paying attention to any of this....."
    That sense of authority is your insecurity.

    Sent from my SM-T810 using Tapatalk

  11. #17336
    Join Date
    Apr 2006
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    SF & the Ho
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    6,239
    Quote Originally Posted by ::: ::: View Post
    what test is Trump getting multiple times each week to determine whether he's got the Corona? (for that matter Pence too)

    after hearing about the swap-up-the-nose one from a friend whose kid had to go to the hospital for a broken arm surgery, i'm sure Trump isn't sitting for that one even a second time...don't even consider multiple each week
    You’re probably right, but i like the thought of someone given him the nurse ratchet treatment every day

  12. #17337
    Join Date
    Sep 2008
    Posts
    10,384
    Quote Originally Posted by Bunion 2020 View Post
    I feel sorry for her that she is sick and married to an asshole.
    really? this is the same shit as with melania... she knew he was an asshole before she married him. fucking eva braun's.
    They got a name for the winners in the world

    http://procatinator.com/?cat=80

  13. #17338
    Join Date
    Dec 2005
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    3,310
    Quote Originally Posted by Ripzalot View Post
    That sense of authority is your insecurity.
    Name:  c39.png
Views: 1342
Size:  137.2 KB

  14. #17339
    Join Date
    Mar 2005
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    Dystopia
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    10,930
    Quote Originally Posted by huckbucket View Post
    I'm not on board yet. Some issues:

    - Site of administration
    - Method of administration (needle-free being shown to be better)
    - Selection of protein to encode (and associated size) versus the need to avoid secondary RNA structure
    - All prior infectious disease work with mRNA vaccines have either directly introduced the RNA into dendritic cells as the vehicle or they have used a carrier like protamine. Not employed for CV as far as I know

    Also, you mention "mRNA therapeutics." Are you still referring to a vaccine with this or do you know of someone who is encoding a therapeutic into mRNA to make the protein in vivo (like an IgG for example)?
    Might need to calibrate sarcasm meter.
    Bozo was /sarc as I read it
    “Life has become immeasurably better since I have been forced to stop taking it seriously.”
    Hunter S. Thompson

  15. #17340
    Join Date
    Apr 2006
    Location
    Funkytown
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    167
    Quote Originally Posted by huckbucket View Post
    I'm not on board yet. Some issues:

    - Site of administration
    - Method of administration (needle-free being shown to be better)
    - Selection of protein to encode (and associated size) versus the need to avoid secondary RNA structure
    - All prior infectious disease work with mRNA vaccines have either directly introduced the RNA into dendritic cells as the vehicle or they have used a carrier like protamine. Not employed for CV as far as I know

    Also, you mention "mRNA therapeutics." Are you still referring to a vaccine with this or do you know of someone who is encoding a therapeutic into mRNA to make the protein in vivo (like an IgG for example)?
    Thanks for your comments on real issues.
    I don't know remotely enough to reply to all of your points.

    I'm a sceptical person. And one of my all time favorite science quotes was from a Genentech guy who skis at Squaw,
    "Why does it take ten or fifteen years to release a drug?"
    "Because shit happens."
    But I kinda feel like I've joined the church of mRNA.

    The Moderna guys come across as good scientists, but also arrogant VC pitch artists. The Precision Nanosystems guys sound reasonable.

    I think that in both the Moderna and Precision NanoSystems videos they mentioned intramuscular injections.

    I'm hopeful about your point about how it's critical to identify what the mRNA is supposed to make. I guess that I've been naively convinced that the spike protein, and mRNA, are well enough understood that they'll have a least one reasonably effective vaccine.

    The whole months of testing for safety and efficacy, and dealing with live humans thing, is alien to me. Computer nerds get impatient if code takes five minutes to compile or synthesize.

    I did have a negative, knee jerk, engineering reaction to Michael Farzan's, maybe you can just make the important part of the spike protein.

    I can't tell if mRNA for antibodies has moved out of the lab, or make sense of what the "RNA-based treatments" are trying to do. I was probably getting carried away by the, "An elegant solution to circumvent the problems of complex production and purification processes and aberrant posttranslational modifications of the antibody, is to deliver the genetic information of the antibody itself."

    How mRNA therapeutics are entering the monoclonal antibody field
    https://translational-medicine.biome...967-019-1804-8

    A lot of groups are putting a lot of effort into identifying a good antibody cocktail for SARS-CoV-2. And investment in mRNA from basic research to production is skyrocketing. So if mRNA technology is fundamentally as good as the evangelists say? And from a big pharma standpoint, seems like antibodies are where the R&D would go post pandemic apocalypse.

  16. #17341
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    Jan 2008
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    truckee
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    13,187
    Quote Originally Posted by Benny Profane View Post
    Let's not forget mentioning Pelosi's solution, which is to open up the Obama exchanges so that the tens of millions of the unemployed would have the right to spend thousands of dollars on health insurance. Yeah, thanks Nancy. What flavor ice cream today?
    You're right--it won't help much, but do you have a better idea, besides flipping the Senate with a 60 blue seats and flipping the WH.
    If there's a silver lining to Covid it might be that we get true universal coverage--single payer or govt subsidized private insurance or a combination, whatever, but something.

  17. #17342
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    Jan 2008
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    truckee
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    Quote Originally Posted by KQ View Post
    back in the day you never ate meat on a Friday Lent or not.
    Nothing quite as disgusting as school cafeteria fish. No meat on Fri in my school, which was 90% plus Jewish. Imagine the uproar if Muslim families demanded that public schools served only halal food.

  18. #17343
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    Jan 2008
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    truckee
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    Quote Originally Posted by uglymoney View Post
    Lolz.

    Sent from my SM-G950U using Tapatalk
    Oh please god--I'm sorry I have doubted your existence. Let the sunovabitch get it too and really, really suffer (but not die, I don't pray for people to die) and I will stop being an atheist--I will go to shul or church or mosque every day (5 times for the mosque), I will become a missionary, I will bleed from my palms and feet, I will not speak for the next 40 years and eat only locusts and wear only a loin cloth no matter how cold it is--whatever you tell me to do. But please give it to that asshole. Please.

  19. #17344
    Join Date
    Oct 2003
    Location
    Big in Japan
    Posts
    41,824
    Quote Originally Posted by mcphee View Post
    Catholics only or was this a widely accepted cultural practice? My entire family is Catholic, I went to Catholic school K-8, but I only remember it as a Lent thing.
    You're going to hell.

    Let's do some livin'
    After, we die

  20. #17345
    Join Date
    Jan 2008
    Location
    truckee
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    13,187
    Quote Originally Posted by ::: ::: View Post
    what test is Trump getting multiple times each week to determine whether he's got the Corona? (for that matter Pence too)

    after hearing about the swap-up-the-nose one from a friend whose kid had to go to the hospital for a broken arm surgery, i'm sure Trump isn't sitting for that one even a second time...don't even consider multiple each week
    If Fauci is giving him the test it's probably a fake test.

  21. #17346
    Join Date
    Oct 2003
    Location
    Big in Japan
    Posts
    41,824
    Quote Originally Posted by old goat View Post
    Oh please god--I'm sorry I have doubted your existence. Let the sunovabitch get it too and really, really suffer (but not die, I don't pray for people to die) and I will stop being an atheist--I will go to shul or church or mosque every day (5 times for the mosque), I will become a missionary, I will bleed from my palms and feet, I will not speak for the next 40 years and eat only locusts and wear only a loin cloth no matter how cold it is--whatever you tell me to do. But please give it to that asshole. Please.
    X2

    She actually married Steven Miller. Pure evil.

    Let's do some livin'
    After, we die

  22. #17347
    Join Date
    Sep 2001
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    The Cone of Uncertainty
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    49,550
    He probably doesn't have it - no way she lets him anywhere near her.

  23. #17348
    Join Date
    Jun 2007
    Location
    Cruzing
    Posts
    9,914
    If he gets it, I'm in for an Ikon, so I can see OG skiing in that loin cloth. From afar. Not sure about sharing a chairlift.

  24. #17349
    Join Date
    Jan 2008
    Location
    truckee
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    13,187
    OK serious question. In my line of work it's generally accepted that irrigating a dirty wound or a belly full of pus or shit with salt water in copious amounts is all that is necessary to reduce bacterial counts to safe numbers. "Dilution is the solution to pollution." No antiseptics necessary--)and possibly harmful in the belly because they can be absorbed into the blood stream). Would the same thing be true of washing produce--soap not necessary; you don't have to kill the virus just wash it down the sink?

  25. #17350
    Join Date
    Sep 2001
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    Before
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    21,778
    If you had the choice between Miller and Kushner getting the covids, to which god would you pray?
    Merde De Glace On the Freak When Ski
    >>>200 cm Black Bamboo Sidewalled DPS Lotus 120 : Best Skis Ever <<<

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