Page 1356 of 1673 FirstFirst ... 1351 1352 1353 1354 1355 1356 1357 1358 1359 1360 1361 ... LastLast
Results 33,876 to 33,900 of 41810
  1. #33876
    Join Date
    Jan 2008
    Location
    truckee
    Posts
    23,111
    Quote Originally Posted by Ottime View Post
    Huh. My wife has been working her ass off since March of last year creating new material that works via zoom calls. Same with all the teachers I know.
    Apologies---should have said back to in-person school

  2. #33877
    Join Date
    May 2002
    Posts
    33,440
    What's the scoop on Invermectin? Just ran into a buddy who said his friend ordered the equine version online for $20 and self-administered (is it a shot?) and told my friend he was now immune. WTF?

  3. #33878
    Join Date
    Aug 2018
    Location
    beaverhead county
    Posts
    4,528
    Quote Originally Posted by splat View Post
    What's the scoop on Invermectin? Just ran into a buddy who said his friend ordered the equine version online for $20 and self-administered (is it a shot?) and told my friend he was now immune. WTF?
    the equine versions of things sound pretty great
    swing your fucking sword.

  4. #33879
    Join Date
    May 2002
    Posts
    33,440
    He said the comparison was that the ingredients were the same as the human version of it, except you get 1200 lbs worth of protection from the equine version. Old Goat?

  5. #33880
    Join Date
    Jan 2006
    Location
    Alpental
    Posts
    6,564
    Quote Originally Posted by splat View Post
    He said the comparison was that the ingredients were the same as the human version of it, except you get 1200 lbs worth of protection from the equine version. Old Goat?
    Dood, there is no immunity from that DRUG. Taking it prophylactically isn't going to do much at all other than part you with $.

    "Ivermectin has been shown to inhibit the replication of SARS-CoV-2 in cell cultures.13 However, pharmacokinetic and pharmacodynamic studies suggest that achieving the plasma concentrations necessary for the antiviral efficacy detected in vitro would require administration of doses up to 100-fold higher than those approved for use in humans.1"

    Not advised.
    Move upside and let the man go through...

  6. #33881
    Join Date
    May 2002
    Posts
    33,440
    Thanks, Mofro!!! I always appreciate your input on these things.

  7. #33882
    Join Date
    Dec 2005
    Posts
    11,146
    Widely shared vitamin D-COVID-19 preprint removed from Lancet server

    https://retractionwatch.com/2021/02/...8P6SSWajyMWig4

    We have removed this preprint due to concerns about the description of the research in this paper. This has led us to initiate an investigation into this study.

  8. #33883
    Join Date
    Dec 2010
    Posts
    670
    Quote Originally Posted by bennymac View Post
    Widely shared vitamin D-COVID-19 preprint removed from Lancet server

    https://retractionwatch.com/2021/02/...8P6SSWajyMWig4

    We have removed this preprint due to concerns about the description of the research in this paper. This has led us to initiate an investigation into this study.
    Well that sucks. It seems like so many treatment methods see initial positive results only to be pulled back.

  9. #33884
    Join Date
    Jan 2008
    Location
    truckee
    Posts
    23,111
    Re ivermectin--draw your own conclusions
    https://www.covid19treatmentguidelin...py/ivermectin/
    most of the studies showed no benefit. One multicenter randomized trial showed improved mortality compared to control--but the "control" group got hydroxychloroquine, not placebo, so hypothetically the hcq could have been killing the patients, not Covid. Other than the lack of placebo that was the best trial and the largest so the results can't be poopooed.

    On a positive note--retrospective follow up in the UK showed good effectiveness of a single dose of AZ and Pfizer including in the elderly.
    https://www.washingtonpost.com/world...e75_story.html
    The study group was 1.1M Scots who got the vaccine vs 3.3M Scots who didn't. (IE they studied the whole country.)

    Biden held a ceremony today to remember 500,000 US deaths. Wonder what they're planning for 600,000.
    Last edited by old goat; 02-22-2021 at 04:45 PM.

  10. #33885
    Join Date
    Dec 2004
    Location
    Where the sheets have no stains
    Posts
    22,065
    Half a million people dead. FFS

    Go back and read the first 5 pages of this thread I dare ya, we were pretty blase. 1 year and 1 month later and here we are.

    Has anyone else wondered about "The 2020/21 flu season has been and remains unusually mild, according to the CDC".

    More people getting vaccinated? More hand washing, masks and SDing?
    I have been in this State for 30 years and I am willing to admit that I am part of the problem.

    "Happiest years of my life were earning < $8.00 and hour, collecting unemployment every spring and fall, no car, no debt and no responsibilities. 1984-1990 Park City UT"

  11. #33886
    Join Date
    Dec 2012
    Location
    I can still smell Poutine.
    Posts
    24,504
    Quote Originally Posted by Bunion 2020 View Post
    Half a million people dead. FFS

    Go back and read the first 5 pages of this thread I dare ya, we were pretty blase. 1 year and 1 month later and here we are.

    Has anyone else wondered about "The 2020/21 flu season has been and remains unusually mild, according to the CDC".

    More people getting vaccinated? More hand washing, masks and SDing?
    Agree.

    Agree.

    Yes.

    Yes and yes.

  12. #33887
    Join Date
    Oct 2010
    Posts
    1,951
    Quote Originally Posted by Bunion 2020 View Post
    Has anyone else wondered about "The 2020/21 flu season has been and remains unusually mild, according to the CDC".

    ?
    Nothing to wonder about, really. Influenza is transmitted in similar ways to COVID, but is less virulent. Even the states half-assing COVID measures have significant populations distancing, masking, washing hands, etc. it’s almost like basic public health measures work!

  13. #33888
    Join Date
    Dec 2012
    Location
    I can still smell Poutine.
    Posts
    24,504
    Quote Originally Posted by Falcon3 View Post
    Nothing to wonder about, really. Influenza is transmitted in similar ways to COVID, but is less virulent. Even the states half-assing COVID measures have significant populations distancing, masking, washing hands, etc. it’s almost like basic public health measures work!
    Almost seems like it.

  14. #33889
    Join Date
    Oct 2003
    Location
    In Your Wife
    Posts
    8,291
    Quote Originally Posted by old goat View Post
    Biden held a ceremony today to remember 500,000 US deaths. Wonder what they're planning for 1,000,000.
    FIFY.

  15. #33890
    Join Date
    Nov 2005
    Posts
    8,318
    Quote Originally Posted by old goat View Post
    LA Times story about herd immunity
    https://www.sacbee.com/news/nation-w...249395835.html

    I'm skeptical, especially since immunity from natural asymptomatic infection is likely to be short lived and not effective against variants due to lower antibody levels than from vaccine, especially 2 vaccine doses : -- )
    Ok, Dr Two-dose, here's the question that keeps ringing in my head: if we're concerned about dropping down to one dose for mRNA's, should we also try to avoid the J&J/AZ vaccines because of their slightly lower efficacy numbers?

    I feel like at some point Dr F is gonna have to answer that one since they've come out in support of "whichever vaccine you're offered" already (I'm regarding Dr. Fauci as the spokesman at this point). If a 90% effective J&J is good enough, what's wrong with offering more mRNAs at 90%+? (Full disclosure, I'm going to get the second shot.)

  16. #33891
    Join Date
    May 2007
    Location
    Sandy, Utah
    Posts
    14,410
    Quote Originally Posted by glademaster View Post
    FIFY.
    Brings up a decent question. What if things actually get way worse before they get measurably better? Is it "someones" fault? Thats how we've thought about this thing the entire time...the politics of it all suck balls.

  17. #33892
    Join Date
    Jan 2005
    Location
    Access to Granlibakken
    Posts
    11,184
    A coronavirus variant that emerged in mid-2020 and surged to become the dominant strain in California not only spreads more readily than its predecessors, but also evades antibodies generated by COVID-19 vaccines or prior infection and it’s associated with severe illness and death, researchers said.

    In a study that helps explain the state’s dramatic surge in COVID-19 cases and deaths — and portends further trouble ahead — scientists at UC San Francisco said the cluster of mutations that characterizes the homegrown strain should mark it as a “variant of concern” on par with those from the United Kingdom, South Africa and Brazil.
    Ugh.

  18. #33893
    Join Date
    Jan 2011
    Location
    Alta
    Posts
    2,931
    ^^^
    What should really sink in is that South Africa and Brazil were both able to identify mutant strains before the USA. Anyone with half a brain had to know that mutations would be popping up here. Were the global leader in infections! There’s probably more mutations here than anywhere else. But we aren’t sequencing at the rate other countries are (even South Africa and Brazil).

  19. #33894
    Join Date
    Nov 2008
    Posts
    9,853
    Well, every body knows that the sequencers were designed by Hugo Chavez and the components smuggled in via rectal insertion, and then programmed and operated by the Squad. And they only employed pedophiles, of course, so it was obviously in our best interests NOT to use those unpatriotic ticking bombs.

  20. #33895
    Join Date
    Oct 2010
    Posts
    1,951
    Quote Originally Posted by PB View Post
    Well, every body knows that the sequencers were designed by Hugo Chavez and the components smuggled in via rectal insertion, and then programmed and operated by the Squad. And they only employed pedophiles, of course, so it was obviously in our best interests NOT to use those unpatriotic ticking bombs.
    I’m a just a simple man, but that all sounds right to me!

  21. #33896
    Join Date
    Jan 2008
    Location
    truckee
    Posts
    23,111
    Quote Originally Posted by jono View Post
    Ok, Dr Two-dose, here's the question that keeps ringing in my head: if we're concerned about dropping down to one dose for mRNA's, should we also try to avoid the J&J/AZ vaccines because of their slightly lower efficacy numbers?

    I feel like at some point Dr F is gonna have to answer that one since they've come out in support of "whichever vaccine you're offered" already (I'm regarding Dr. Fauci as the spokesman at this point). If a 90% effective J&J is good enough, what's wrong with offering more mRNAs at 90%+? (Full disclosure, I'm going to get the second shot.)
    I'm not in favor of one dose or two dose. Not in my job description. I'm in favor of whatever the experts decide. I'm just parsing the arguments.

    As I said before, the problem with going to one dose with Moderna and Pfizer is that doing this in the general population without a formal study is that no one will know when the protection lapses until we get a big surge, and then they'll have to figure out if the surge is a new strain or lapsed immunity. Presumably the people who got 2 doses of the mRNA vaccines as part of the phase 3 trials will be followed for years--I hope, so if they start getting sick the cases can be quickly investigated and people can start getting boosters for whatever strain is the cause. If they do decide to go to one dose on the mRNA vaccines I hope they can identify a study population that they can continue to follow. AFAIK for the general population once you walk out of the clinic after your second dose you're on your own.

    To put it more succinctly the issue is not whether you give one dose or two but whether you continue to follow the one dose patients the way the Phase 3 2 dose patients are followed.

    The kind of follow up that I'm talking about might be possible in Scotland--small country that keeps good track of the health of its citizens. Another place that could do it would be Denmark--all kinds of population health studies come out of there because they keep health records on the entire population. If you can follow your entire population you don't need to segregate a study population ahead of time.

  22. #33897
    Join Date
    Nov 2005
    Posts
    8,318
    Quote Originally Posted by old goat View Post
    I'm not in favor of one dose or two dose. Not in my job description. I'm in favor of whatever the experts decide. I'm just parsing the arguments.

    As I said before, the problem with going to one dose with Moderna and Pfizer is that doing this in the general population without a formal study is that no one will know when the protection lapses until we get a big surge, and then they'll have to figure out if the surge is a new strain or lapsed immunity. Presumably the people who got 2 doses of the mRNA vaccines as part of the phase 3 trials will be followed for years--I hope, so if they start getting sick the cases can be quickly investigated and people can start getting boosters for whatever strain is the cause. If they do decide to go to one dose on the mRNA vaccines I hope they can identify a study population that they can continue to follow. AFAIK for the general population once you walk out of the clinic after your second dose you're on your own.

    To put it more succinctly the issue is not whether you give one dose or two but whether you continue to follow the one dose patients the way the Phase 3 2 dose patients are followed.

    The kind of follow up that I'm talking about might be possible in Scotland--small country that keeps good track of the health of its citizens. Another place that could do it would be Denmark--all kinds of population health studies come out of there because they keep health records on the entire population. If you can follow your entire population you don't need to segregate a study population ahead of time.
    Obviously I'm just spitballing here, so not really looking to take a firm position on it, either. The recent numbers out of Scotland and Israel were what got me thinking the mRNAs might already be showing greater effectiveness in one dose than J&J. Which would start begging questions like this-- unless we're already too late to do anything but variant-specific boosters?

  23. #33898
    Join Date
    Jan 2008
    Location
    truckee
    Posts
    23,111
    I wonder how much J and J we'll actually see--seems like a lot of the production might be headed for places without freezers.

    I should add that if the plan is to get everyone a second dose within a few months a lot of objections go away, although not the concern about effectiveness against variants. Of course things don't always go as planned, especially if the drug companies have to stop making doses to work on vaccines against variants. (I learned that the major bottleneck in manufacturing the lipid nanoparticles that carry the mRNA into the cells--since that process won't change with variant vaccines it may be that creating boosters won't slow down overall vaccine availability.)
    Last edited by old goat; 02-23-2021 at 08:39 PM.

  24. #33899
    Join Date
    Feb 2019
    Posts
    330
    Quote Originally Posted by old goat View Post
    LA Times story about herd immunity
    https://www.sacbee.com/news/nation-w...249395835.html

    I'm skeptical, especially since immunity from natural asymptomatic infection is likely to be short lived and not effective against variants due to lower antibody levels than from vaccine, especially 2 vaccine doses : -- )
    I wasn’t aware that the vaccines provide complete immunity for everyone who gets them... I was under the assumption that the medical professionals told everyone it was just to limit severity of symptoms as you still have to wear a mask and social distance since you can give it to other people/still get it.

  25. #33900
    Join Date
    Nov 2005
    Posts
    8,318
    Quote Originally Posted by mtuhockey33 View Post
    I wasn’t aware that the vaccines provide complete immunity for everyone who gets them... I was under the assumption that the medical professionals told everyone it was just to limit severity of symptoms as you still have to wear a mask and social distance since you can give it to other people/still get it.
    So you're saying you're adjusting your understanding to account for the mistake in your assumption? Are you removing the word "just" and accounting for the fact that some will also get "complete immunity" or do you need to flip from one absolute to another?

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •