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Thread: The Nutrition Science thread
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05-17-2019, 01:58 PM #576
That is a really, really robust study. Had to cost a shit-ton to run. It would be cool to see it repeated, because it basically validates everything I've said here about nutrition. Full text is available: https://www.cell.com/cell-metabolism...131(19)30248-7
Check out the Graphical Abstract:
Ad libitum feeding (eat as much as you want) and the unprocessed group consistently ate 500 kcal fewer per day. That's massive. And look at the BW trend lines! Processed group quickly gained some weight then leveled off, while the unprocessed group steadily lost weight. Plus, that was while eating ~2,500 kcal/day, certainly no crash diet.
Fat mass change also accelerated during the course of the study, for both diets:
Also, this statement from the author in the NPR article has huge significance:
"For example, when the participants were eating the unprocessed diet, they had higher levels of an appetite-suppressing hormone called PYY, which is secreted by the gut, and lower levels of ghrelin, a hunger hormone, which might explain why they ate fewer calories. On the ultra-processed diet, these hormonal changes flipped, so participants had lower levels of the appetite-suppressing hormone and higher levels of the hunger hormone."
Bottom line, highly processed foods mess up your body's hormonal response to food, and everything goes to shit from there.
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05-17-2019, 02:03 PM #577
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05-17-2019, 02:27 PM #578
Sometimes quickly, sometimes slowly.
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05-17-2019, 04:42 PM #579
I have been eating a super clean high fat, high protein diet for about 2 years now and just got my second blood panel results back....
2018
Total cholesterol: 146
HDL: 67
LDL: 67
2019
Total cholesterol: 152
HDL: 77
LDL: 66
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05-17-2019, 05:01 PM #580
hubby does ghee and coconut oil in his coffee every morning for several yrs now
I never got into it but in summer he starts his days early at like 5am (he's a wildlife guide so early starts) and this helps him get though until breakfast with his guests around 8-9am.
I prefer your style- on a nice piece of toast
Also re: the processed vs unprocessed study being reported on- 1st thought was "no shit, sherlock"
but very glad a good, comprehensive study was done so that it hopefully shifts overall nutrition standards bc I sometimes forget how bad nutrition is in other places
particularly with kids and how they serve them cr@p in most public schoolsskid luxury
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05-17-2019, 09:14 PM #581
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05-17-2019, 09:53 PM #582
I think the page which details the actual diets eaten is interesting:
https://www.cell.com/cms/10.1016/j.c...925189f1b/mmc1
the processed meals are mostly unsurprising, the unprocessed meals include basmati rice & regular pasta
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05-17-2019, 09:56 PM #583Funky But Chic
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what do we think about glutathione supplements?
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05-21-2019, 11:42 AM #584
The difference in the sheer volume of food between the two sets of meals is striking. Also, apparently the processed diet eaters ate 54x more added sugar
While they were included in some meals, white rice and pasta were definitely not staples of the unprocessed diet. The amounts were pretty modest and the meals included enough veggies and fiber-rich items to keep the meal's overall GI down. Regardless, it's not like I'm opposed to starch. I'm lucky if a 15-lb Costco bag of Yukon Golds lasts me two weeks.
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05-21-2019, 05:39 PM #585
A women I met from Budapest at burning man sent me a bottle of pumpkin seed oil from overseas which I am absolutely loving. Don't cook with it, but it's flavor is out of this world.
Try some. It's supposedly good for you too.
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05-21-2019, 06:13 PM #586Funky But Chic
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05-21-2019, 06:15 PM #587Registered User
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05-22-2019, 11:03 AM #588
This is the top result on google for "glutathione supplements": https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162377/
"Oral GSH supplementation (500 mg twice daily) was given to the volunteers for 4 weeks...No significant changes were observed in biomarkers of oxidative stress, including glutathione status, in this clinical trial of oral glutathione supplementation in healthy adults."
Which makes sense given that it's poorly absorbed orally. Precursors like N-AC may work better to boost endogenous production, but basically all "generally recognized as healthy" foods are rich in precursors and are most likely the best way to get them. So, eat meat/eggs/legumes/tubers/vegetables/fruit, get plenty of sleep, exercise, limit alcohol.
https://www.healthline.com/nutrition...se-glutathioneLast edited by Dantheman; 05-22-2019 at 11:25 AM.
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05-22-2019, 01:01 PM #589
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05-22-2019, 03:10 PM #590
https://draxe.com/pumpkin-seed-oil/
I drizzle it on almost anything. Mostly greens though.
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05-22-2019, 04:39 PM #591
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05-22-2019, 04:42 PM #592User
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05-22-2019, 04:43 PM #593
Yeah. I bring it back when I'm in eastern Austria. It's delicious with carrots.
I stopped eating pumpkin seeds with breakfast after the grocery store near the office stopped carrying them in the bulk section. I should fix that. I usually did a bowl of 1:3:3 pumpkin seeds, uncooked rolled oats, plain yogurt
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05-22-2019, 05:41 PM #594
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07-18-2019, 11:17 AM #595
A very interesting (mouse) study investigating the relationship between weight loss/fat burning and something known as the receptor for advanced glycation end products (RAGE): https://www.theatlantic.com/health/a...oteins/594073/
TL;DR version: Activation of RAGE drastically suppresses fat-burning and BMR. Mice with their RAGE pathway genetically deleted gained 70% less weight than conventional mice when fed an obesigenic diet.
Why does this matter? First, besides being activated directly by AGE, RAGE is activated by stress (including undereating) and overeating. The overeating part makes some evolutionary sense, especially in the context of the relationship between insulin and HSL; a hunter-gatherer who found a food windfall would benefit from preferentially storing those calories as fat. The undereating part does too; if you're not finding enough food conserving your existing fat stores is beneficial to your survival.
Now, transpose that context into modern life where people are typically chronically stressed, chronically overeat, and their bloodstreams are flooded with endogenous AGE from chronic hyperglycemia. AGE are inflammatory, and activation of RAGE activates other pro-inflammatory genes, creating a positive feedback loop. No wonder everyone is fat and sick. Diseases with a known or suspected causal relationship with RAGE include:
Alzheimer's disease
Arthritis
Atherosclerosis
Congestive heart failure
Diabetic neuropathy
Diabetic nephropathy
Diabetic retinopathy
Myocardial infarction
Peripheral vascular disease
Psoriasis
Rheumatoid arthritis
Takayasu's arteritis
https://en.wikipedia.org/wiki/Advanc...on_end-product
https://en.wikipedia.org/wiki/RAGE_(receptor)
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08-04-2019, 08:57 PM #596
This whole change has been an interesting journey. Keto is fascinating in its own right, but it also led me to IF, which I practice as a general thing, usually 16/8 but once every week or two I may go 20 hours or longer without eating. Not having to eat, not feeling hungry, is a trip. I still marvel at it.
And I can exercise while doing this. Last summer, when I was new to it, I found I had to take in some carbs (usually gatorade) right before doing something like mt biking, or I would just feel gassed the whole ride whenever I had to charge up a hill. This year, I don't need it. I go biking without the gatorade and feel just fine; I think I must be fully fat adapted, able to burn the fuel at hand. This morning, I had 2 cups of coffee, each with a dollop of heavy cream. At 1pm, I went on a 2 hour mt bike ride, maybe 10 miles and 1300' of climbing (yeah, probably slow pace for some of you people, but that's my pace so fuckit). Hadn't eaten anything. Felt fine, not hungry and not gassed. What the fuck? What is this strange sorcery going on inside my body?
So, yeah, I'm that guy, the punchline to the joke, "how do you tell someone is keto?" (alternate version: ski patroller, raft guide, does crossfit, etc) Answer: they'll tell you. Yeah, me, that guy, lol."fuck off you asshat gaper shit for brains fucktard wanker." - Jesus Christ
"She was tossing her bean salad with the vigor of a Drunken Pop princess so I walked out of the corner and said.... "need a hand?"" - Odin
"everybody's got their hooks into you, fuck em....forge on motherfuckers, drag all those bitches across the goal line with you." - (not so) ill-advised strategy
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08-04-2019, 09:21 PM #597
Try that same ride next time and push yourself. No sugar or carbs to utilize, your body won’t be able to do it.
Sent from my iPhone using TGR Forums
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08-04-2019, 10:16 PM #598"fuck off you asshat gaper shit for brains fucktard wanker." - Jesus Christ
"She was tossing her bean salad with the vigor of a Drunken Pop princess so I walked out of the corner and said.... "need a hand?"" - Odin
"everybody's got their hooks into you, fuck em....forge on motherfuckers, drag all those bitches across the goal line with you." - (not so) ill-advised strategy
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10-01-2019, 11:10 PM #599
Fire up that grill!
https://www.vox.com/science-and-heal...health-effects
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10-02-2019, 11:28 AM #600
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