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  1. #1051
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    This is going to be revolutionary. Not kidding

    https://www.globenewswire.com/news-r...py-for-Tr.html

    Clif Notes: Using a precision enzymatic approach called CRISPR, this new technology can be administered therapeutically and specifically to the liver to inactivate an aberrant gene called TTR which is the cause of Transthyretin Amyloidosis. The promise for the future is repair of gene defects associated with disease, starting with other monogenic disorders. In my line of work I've heard CEO's claim their technology will be revolutionary a billion times, yet this time feels very different. Big step forward.

    “These are the first ever clinical data suggesting that we can precisely edit target cells within the body to treat genetic disease with a single intravenous infusion of CRISPR. The interim results support our belief that NTLA-2001 has the potential to halt and reverse the devastating complications of ATTR amyloidosis with a single dose,” said Intellia President and Chief Executive Officer John Leonard, M.D. “Solving the challenge of targeted delivery of CRISPR/Cas9 to the liver, as we have with NTLA-2001, also unlocks the door to treating a wide array of other genetic diseases with our modular platform, and we intend to move quickly to advance and expand our pipeline. With these data, we believe we are truly opening a new era of medicine.”

  2. #1052
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    Holy shit.

  3. #1053
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    Cool. Yeah, the potential and scientific importance of the development of CRISPR/CAS9 cannot be overstated.

  4. #1054
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    Quote Originally Posted by LegoSkier View Post
    Cool. Yeah, the potential and scientific importance of the development of CRISPR/CAS9 cannot be overstated.
    CRISPR/CAS9 itself is hardly new, but targeted in vivo delivery without adverse effects? Holy. Fucking. Shit. That's the holy grail right there.

  5. #1055
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    Paywalled, but for those with a sub;

    https://www.nejm.org/doi/full/10.1056/NEJMoa2107454

  6. #1056
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    Next step in cancer immunotherapy: https://medicalxpress.com/news/2021-...umor-rest.html

  7. #1057
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    Oct 2003
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    写道
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    ^ Variations of that have been on-going for twenty years.
    Daniel Ortega eats here.

  8. #1058
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    Quote Originally Posted by Dantheman View Post
    Already working in relapsed or refractory, CD19-positive NHL and CLL in the clinic.

    Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors
    https://www.nejm.org/doi/pdf/10.1056...icleTools=true
    Liu E, Marin D, Banerjee P et al. N Engl J Med 2020; 382:545-553​

    Overall Response Rate = 73% (8/11)​
    Complete Responses = 64% (7/11) – (3 with CLL, 4 with lymphoma)​

  9. #1059
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    Sep 2001
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    Maybe this is more like Cool Engineering, but hey, there's math stuff in this thread, so the drift has already existed.

    Merde De Glace On the Freak When Ski
    >>>200 cm Black Bamboo Sidewalled DPS Lotus 120 : Best Skis Ever <<<

  10. #1060
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    Hawking's black hole area theorem observationally confirmed: https://news.mit.edu/2021/hawkings-b...m-confirm-0701

  11. #1061
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    Quote Originally Posted by Buster Highmen View Post
    Maybe this is more like Cool Engineering, but hey, there's math stuff in this thread, so the drift has already existed.

    Super cool. I wonder how somebody would invest in them.

  12. #1062
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    Why is GMGMF trading with a market cap of $130M if this tech is so close? Seems like a multi billion dollar idea and worth $100s of billions if executed.

  13. #1063
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    Jan 2017
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    Quote Originally Posted by ötzi View Post
    Super cool. I wonder how somebody would invest in them.
    only "accredited investors" at this point....

  14. #1064
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    Euler was Swiss.
    Merde De Glace On the Freak When Ski
    >>>200 cm Black Bamboo Sidewalled DPS Lotus 120 : Best Skis Ever <<<

  15. #1065
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    Methane on Enceladus is either 1) biogenic; or 2) Enceladus formed through the accretion of organic-rich material supplied by comets and that primordial organic matter is breaking down via chemical processes that do not occur on Earth: https://phys.org/news/2021-07-methan...enceladus.html

  16. #1066
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    Device taps brain waves to help paralyzed man communicate
    https://techxplore.com/news/2021-07-...paralyzed.html

  17. #1067
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    ^^ They had that in the Times this morning, cool stuff.

    https://www.nytimes.com/2021/07/14/h...sultPosition=1

  18. #1068
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    AlphaFold predicts the structure of 350,000 proteins
    https://www.bbc.com/news/science-environment-57929095

  19. #1069
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  20. #1070
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    https://thehill.com/changing-america...9B4o-sbeUc6o_8


    Sent from my iPhone using TGR Forums
    `•.¸¸.•´><((((º>`•.¸¸.•´¯`•.¸.•´¯`•...¸><((((º>

    "Having been Baptized by uller his frosty air now burns my soul with confirmation. I am once again pure." - frozenwater

    "once i let go of my material desires many opportunities for playing with the planet emerge. emerge - to come into being through evolution. ok back to work - i gotta pack." - Slaag Master

    "As for Flock of Seagulls, everytime that song comes up on my ipod, I turn it up- way up." - goldenboy

  21. #1071
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    May 2002
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    Quote Originally Posted by ötzi View Post
    Super cool. I wonder how somebody would invest in them.
    Apparently, there are pre IPO opportunities here, ice.

    https://equityzen.com/?flow=signup

  22. #1072
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    May 2009
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    Wanna (simulate) live on Mars?
    4 lucky people — it could be you!

    https://apnews.com/article/182cc6373...20df2fc637b85a

    The application process opened Friday and they’re not seeking just anybody. The requirements are strict, including a master’s degree in a science, engineering or math field or pilot experience. Only American citizens or permanent U.S. residents are eligible. Applicants have to be between 30 and 55, in good physical health with no dietary issues and not prone to motion sickness.

  23. #1073
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    The bears and Indigenous humans of coastal British Columbia have more in common than meets the eye. The two have lived side by side for millennia in this densely forested region on the west coast of Canada. But it’s the DNA that really stands out: A new analysis has found that the grizzlies here form three distinct genetic groups, and these groups align closely with the region’s three Indigenous language families.

    It’s a “mind-blowing” finding that shows how cultural and biological diversity in the region are intertwined, says Jesse Popp, an Indigenous environmental scientist at the University of Guelph who was not involved with the work.

    The research began purely as a genetics study. Grizzlies had recently begun to colonize islands along the coast of British Columbia, and scientists and Indigenous wildlife managers wanted to know why they were making this unprecedented move. Luckily, in 2011, the region’s five First Nations set up a collaborative “bear working group” to answer exactly that sort of question. Lauren Henson, a conservation scientist with the Raincoast Conservation Foundation, partnered with working group members from the Nuxalk, Haíɫzaqv, Kitasoo/Xai’xais, Gitga’at, and Wuikinuxv Nations to figure out which mainland grizzlies were most genetically similar to the island ones.
    https://www.sciencemag.org/news/2021...guage-families


    DNA analysis reveals three distinct genetic groups of grizzly bears, which align with the boundaries between Indigenous language families (gray lines)

    Click image for larger version. 

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  24. #1074
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    Nov 2008
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    Wait .... bears and people are having ...... SEX?!?!?

  25. #1075
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    Quote Originally Posted by abraham View Post
    https://www.sciencemag.org/news/2021...guage-families


    DNA analysis reveals three distinct genetic groups of grizzly bears, which align with the boundaries between Indigenous language families (gray lines)

    Click image for larger version. 

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    That’s super interesting. It would make sense that the same influences that defined human ranges also define other apex predators

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