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  1. Replies
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    In natural infection, the magnitude of the immune...

    In natural infection, the magnitude of the immune response correlates pretty well with severity of symptoms- getting really sick and surviving generates more immunity than mild infection, which is...
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    Heterogeneity in the immune response, small dose...

    Heterogeneity in the immune response, small dose exposures, and tricks the live virus does to dampen an immune response, all mean lower levels of protection from infection than achievable using a...
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    For one this RM guy got the "Fear Flu" and not...

    For one this RM guy got the "Fear Flu" and not COVID-19. Covids don't really care if you fear them or not, they mostly want to party in the nose, mouth and lungs of anyone entering their airspace,...
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    As a mad scientist who has waffled between making...

    As a mad scientist who has waffled between making vaccines to improve humanity and dreaming up the Sar-bola like viruses to wipe out humanity, I'm a little jealous if someone else beat me to it on...
  5. Pass

    Pass
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    Prefusion stabilized spike does not fall apart.

    Prefusion stabilized spike does not fall apart.
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    Vaccines go through phase I, II, and III trials,...

    Vaccines go through phase I, II, and III trials, and efficacy doesn't come in to play until phase III. Phase I and II track dosing for 1) side effects and 2) induction of a measurable metric that is...
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    First of all, no one is discounting the concept...

    First of all, no one is discounting the concept that if you have had a previous infection with Sars2, that your 1st vaccine may give a higher level of side effects than if you have not been...
  9. My Mrs fired off an email during the crash this...

    My Mrs fired off an email during the crash this morning about things going down during to check out, and this was the response back:
  10. Replies
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    1. Going to Urgent Care for...anything urgent. ...

    1. Going to Urgent Care for...anything urgent.

    Unless you are a Foreigner.

    FHnNIoNUZig
  11. After the initial boot out during ticket...

    After the initial boot out during ticket confirmation #1 and 1hr wait to get back in, was able to get tix for both Sat and Sun booked and barcodes sent.
  12. reservation system just hanging on "processing...

    reservation system just hanging on "processing order".
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    Me too, but we were going 75 and it was raining...

    Me too, but we were going 75 and it was raining pretty good at the time.

    372912

    Snowblading was best done with Sorels or hightop snowskate shoes iirc.
  14. I was told a cap at 1500 tickets/day. Scarcity...

    I was told a cap at 1500 tickets/day. Scarcity creates demand?
  15. Replies
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    con't Durability and future challenges...

    con't


    Durability and future challenges
    Preclinical and early results from human trials show that both vaccines generate anti-S protein IgG and virus-specific neutralizing antibody responses for...
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    COVID-19 vaccines: modes of immune activation and...

    COVID-19 vaccines: modes of immune activation and future challenges
    Nature Reviews Immunology volume 21, pages195197(2021) John R. Teijaro & Donna L. Farber
    ...
  17. Replies
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    Let's review then. Antigen + Adjuvant....

    Let's review then.

    Antigen + Adjuvant.
    Adaptive + Innate.

    Dosing people with 30-100ug of say a TLR7/8, RIG-I,MD5 adjuvant, even one that is engineered for reduced responses, WILL give a...
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    Sort of blending how T cell epitope recognition...

    Sort of blending how T cell epitope recognition works (processing into small bits, peptide epitope display) and B cell epitope recognition of 3D surface Spike structures. The latter is accomplished...
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    https://www.cdc.gov/vaccines/covid-19/health-depar...

    https://www.cdc.gov/vaccines/covid-19/health-departments/breakthrough-cases.html



    As of April 13, 2021, more than 75 million people in the United States had been fully vaccinated against...
  20. Thread: Wagon Stoke

    by Mofro261
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    Saw this beauty of a ski mobile in the lot last...

    Saw this beauty of a ski mobile in the lot last Sunday

    372324
  21. Replies
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    Giving people the Herp? No. Causing the Herp...

    Giving people the Herp? No.

    Causing the Herp they already have to flair up? Yes.
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    I know, but consider it as a vaccine for your...

    I know, but consider it as a vaccine for your attention span.
  23. Replies
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    If you have the time, highly recommend listening...

    If you have the time, highly recommend listening to Dr. Crotty discuss natural immunity following COVID-19, 100-fold differences (heterogeneity) in immune responses among the infected, superior...
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    Color coded for tracking 5 immune parameters over...

    Color coded for tracking 5 immune parameters over time, 5 = all 5 present, red 4 (no cd8), orange 4 (no b cell at 1 mos), blue 4 (no cd4), grey (no IgG). Everyone maintained either IgG or IgA...
  25. Cross posted fro the snowcrummy thread- ...

    Cross posted fro the snowcrummy thread-

    Conditions were well above acceptable.
    371311

    Fun runs with these dudes.
    371312

    April 10, return to winter
    371313
  26. Despite the scary ending on Saturday, goddamn was...

    Despite the scary ending on Saturday, goddamn was that a stoke fueled couple of pow days.

    Plenty of clean palletes to palate
    371311

    Fun runs with these dudes.
    371312

    April 10, return to...
  27. Replies
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    https://www.cdc.gov/coronavirus/2019-ncov/cases-up...

    https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/variant-surveillance/variant-info.html

    https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/variant-proportions.html
    ...
  28. Replies
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    First off, there is no FDA "Light" vs. "Full...

    First off, there is no FDA "Light" vs. "Full Approval". There is EUA approval that doesn't end UNTIL the Emergency declaration is lifted, and then there is traditional appoval for non-emergency use....
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    Availibility driven by decline of the vaccine...

    Availibility driven by decline of the vaccine acceptance with the strongest correlation being who you voted for is a little depressing.
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    The "double mutant" involves L452R (found in CA...

    The "double mutant" involves L452R (found in CA variant) and E484K (or E484Q) (in SA, Br, NY) changes in the Spike protein, but no lineage assignment yet. So far there are vastly more of the UK...
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    Yes, we can. There are 2 naming systems...

    Yes, we can.

    There are 2 naming systems (confusingly) along with a geographic designation.

    B.1.1.7 =UK variant
    B.1.351 =SA variant
    P.1 = Br variant
    B.1.427 / B.1.429 = California variant...
  32. Everything pictured will fit 301. :FIREdevil

    Everything pictured will fit 301. :FIREdevil
  33. Replies
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    Gimme shelter Cant you hear me knockin Sympathy...

    Gimme shelter
    Cant you hear me knockin
    Sympathy for the devil
    2000 light years from home
    Monkey man
  34. I'll have some 208s and 223s with demo clamps...

    I'll have some 208s and 223s with demo clamps available370493.
  35. Replies
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    Lets break this down a bit. We have 102 per...

    Lets break this down a bit.

    We have 102 per ~1.2 Million vaxxed, or roughly 8 per 100,000 who have been vaccinated, that have come down with disease. Let's round to 10, to get 0.01% of those...
  36. Replies
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    Your Mfree108 official Fanboi card should be in...

    Your Mfree108 official Fanboi card should be in the mail.

    Yeah this ski keeps me grinning still with 50ish days on them.
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    Thought we already covered (sic) what happens on...

    Thought we already covered (sic) what happens on Aurora Ave with this pic a few weeks ago.

    Was just at the Lowe's on Thurs to replace a leaky faucet and 3 young women were booking costumer service...
  38. Replies
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    Had Pfizer #1 last Saturday, then skied all day...

    Had Pfizer #1 last Saturday, then skied all day and every day since. Arm was a little sore and had a little fatigue but pow side effects have been awesome. YMMV.
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    368995
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    Hell no. JohnnyCab will get you killed. The...

    Hell no. JohnnyCab will get you killed.

    The driverless Semi trucks these guys are working with that sound equally scary.
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    Positives? I'll put 280" of new at the top of my...

    Positives? I'll put 280" of new at the top of my local hill just during February in the freakin' awesome column.
    No traffic commuting in Seattle for an entire year.
    And puppies.

    367861
    ...
  41. Also 60-70ish days, 70/30 inbounds on Mfree108...

    Also 60-70ish days, 70/30 inbounds on

    Mfree108
    Lotus120
    .....

    At least 75% of days have been in pow so there's little need to ski anything else.

    goes to 11.
  42. Replies
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    Well, not totally accurate. We put our money in...

    Well, not totally accurate. We put our money in vaccine research starting in April/May, gave no money to Pfizer outside of the 50M pre-orders, and actually turned down more doses from them last...
  43. 366977 366978 366979 I heart winter.

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    366978
    366979

    I heart winter.
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    Ta hell w the Covids. Influenza is down 98%. ...

    Ta hell w the Covids.

    Influenza is down 98%.

    Norovirus outbreaks Sept-Mar 2019-20, 180. Sept-Mar 2020-21, 5.

    Keep on keeping on.
  45. As little as possible but always, whatever it...

    As little as possible but always, whatever it takes.

    Never not had a season pass, always been part of the ski equation. Despite being fortunate to have crushed several lifetimes worth of pow,...
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    Dunno if she's mentally ill, but one of my...

    Dunno if she's mentally ill, but one of my neighbors is housing a real nutter.
    ...
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    My pup has been so friendly with other dogs and...

    My pup has been so friendly with other dogs and especially dog owners that we could have named her COVID.
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    Triggered! Congrats on the furkid, feed him...

    Triggered!

    Congrats on the furkid, feed him love and he'll give back much more in return.
  49. As many as 4 courses may be set inside the ropes...

    As many as 4 courses may be set inside the ropes at once- the ski team nearest chair, 2 citileague courses, and masters on the far side. It can be tight in there- I know the kids used to try and wrap...
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    My Mrs when she was preggo with #1: "Will we love...

    My Mrs when she was preggo with #1: "Will we love this kid as much as the dog?"

    Dogs are merely children you can legally leave home unattended without CPS coming to call.

    Nest became empty a...
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