To Vaccinate or Not---The Rat Flu Odyssey Continues

The thalidomide references just blow me away. People are using that as a reason to avoid a vaccine developed today, when the issues with thalidomide usage occurred in an entirely different universe of medical knowledge and study? I mean, FFS, I wasn't born yet and I'm not young, cable TV didn't exist, heck color TV wasn't yet in most people's homes. This all happened around the time that the very first televised presidential debate happened.

It has only slightly more relevance to today's medical world than does the fact that people died of bubonic plague in the middle ages.

Quote:

---

Originally Posted by Danno

The thalidomide references just blow me away. People are using that as a reason to avoid a vaccine developed today, when the issues with thalidomide usage occurred in an entirely different universe of medical knowledge and study? I mean, FFS, I wasn't born yet and I'm not young, cable TV didn't exist, heck color TV wasn't yet in most people's homes. This all happened around the time that the very first televised presidential debate happened.

It has only slightly more relevance to today's medical world than does the fact that people died of bubonic plague in the middle ages.

---

It isn't just Thalidomide. It is a well developed record of BIG PHARMA fraud, false claims and conveniently incomplete data.
It's not like you have to search long and hard for facts about all that.
The skepticism is well deserved, unfortunately.

Viral vectors are designed to deliver most of the proteins needed from viral replication, but instead of the structural genes needed to make the virus particle, the gene of interest is inserted where these would be. All of those other proteins can also generate immune responses that would be considered "off target". This can skew the immune response away from the "target" immunogen, or create a scenario where if a boost is needed, immunity against the other bits prevents the "target" from being made the second time.

Viral vectors and cancer- this occurs when bit of the viral vector get integrated into the host chromosome through homologous recombination. If this happens in a gene, esp a gene involved with cellular regulation, abherrent growth or "cancer" could be a result.

mRNA does not homologously recombine with DNA however- the change from DNA (Thymidine) to RNA (Uracil) prevents the proper hydrogen bonding from occurring. Morever, RNA translation occurs in the cytoplasm and the rough ER, not in the nucleus.

Quote:

---

Originally Posted by TNKen

Safe to say my kids are free-thinking. And I'm not an antivaxxing person. Read the above article. I simply don't want this to be another thalidomide story.

You do understand that this vaccine works on genetic coding and replicating genetic coding? An exciting and new technology, but in its infancy stages.

The idea behind using mRNA to make drugs is based on providing the body with a synthetically-manufactured working copy of our DNA, or another code that we want to read, so that the body itself can go on to make vital proteins that the body lacks, where this deficiency is causing disease.

"The reason that mRNA-based drugs have the potential to be so effective is that they work in the same way as our own genes," says Borgos. "The technology is relatively new, but is predicted to have a bright future. Recently, SINTEF has been participating with other research centers in a large-scale EU project aimed at using the same approach to develop a drug to combat hereditary breast cancer," he explains.

The use of mRNA has great potential in a number of fields, including the treatment of cardiopulmonary, neurological and metabolic diseases. In these cases, the body is instructed to manufacture proteins that may be defective or lacking. However, the world really started paying serious attention to this approach when it became clear that mRNA is very effective in the manufacture of vaccines, such as that being developed to combat the virus SARS-CoV-2, which causes the disease COVID-19.

---

Has mRNA been used in other vaccines or in other medical treatments that have a good multi-year track record affording long term longitudinal studies?

Mofro--Ever hear of Don Coffey?

Quote:

---

Originally Posted by TNKen

Safe to say my kids are free-thinking.

---

Anyone who says they are a free-thinker, I envision an anti-vax, facebook-only educated, conspiracy monger with no critical thinking skills.

Anytime I call someone a free-thinker, it's an insult. A free thinker means they have thoughts free from the problems and complications of critical thinking.

Just a heads up to you, as I'm not here for the gangbang.

Quote:

---

Originally Posted by The AD

What if it ends up being more like "Shaun of the Dead" because that shit was hilarious.

---

Yes it was. Lets hope for comedy.

Quote:

---

Originally Posted by puregravity

Has mRNA been used in other vaccines or in other medical treatments that have a good multi-year track record affording long term longitudinal studies?

---

Not in other vaccines.
Not in other treatments that have a multi-year record.
Off the top of my head I can't remember if any mRNA therapies have been approved yet but there are several currently in clinical trials. Sames goes for CRISPR-Cas9.
The tech is not new, what has severely limited its application in-vivo is the difficulty of getting an mRNA to make it into a cell and survive degradation. We know how to handle what goes inside the package but we're not dialet yet on proper packaging and delivery.

PG, do you generally refuse to approach any new tech for a period of 10-15 years to ensure it's safe? Just curious. I get the higher concern for something that can potentially affect your health, I'm just wondering if you're equally reluctant to consider anything novel as most likely unsafe until proven otherwise.
The multi-year track record requirement always amuses me when applied to pharma. Most people who clamor for it have never once had the same thought about what goes in their food, or pretty much anything they interact with directly. Their perception of risk is so skewed it's not even funny.

Quote:

---

Originally Posted by muted

Anytime I call someone a free-thinker, it's an insult. A free thinker means they have thoughts free from the problems and complications of critical thinking.

---

Agreed. At this point it's just a euphemism for someone who doesn't believe in science but automatically believes any conspiracy theory that comes down the pike.

More Americans died yesterday than died on D-Day.


Attachment 352351


Sent from my iPhone using TGR Forums

Hey LIBTARDS ... by all means take the fucking vaccine you fucking pussies.

Please all go sterile from it and help the human race out. kthnx

Quote:

---

Originally Posted by pappag

Hey LIBTARDS ... by all means take the fucking vaccine you fucking pussies.

Please all go sterile from it and help the human race out. kthnx

---

This is what I'm talking about with the fear. Dude's fucking shitting himself over the vaccine, terrified at the thought of getting it because he doesn't understand anything about it, yet is out there calling "libtards" pussies and probably thinks cause they live their lives in fear of the virus. This level of projection and cognitive dissonance should be fatal and yet, this twat is alive and well. Go figure...

Quote:

---

Originally Posted by Harry

More Americans died yesterday than died on D-Day.


Sent from my iPhone using TGR Forums

---

Maybe we'll take it seriously when we hit Hiroshima numbers.

Quote:

---

Originally Posted by Boissal

This is what I'm talking about with the fear. Dude's fucking shitting himself over the vaccine, terrified at the thought of getting it because he doesn't understand anything about it, yet is out there calling "libtards" pussies and probably thinks cause they live their lives in fear of the virus. This level of projection and cognitive dissonance should be fatal and yet, this twat is alive and well. Go figure...

---

Don't feed the trolls...

Quote:

---

Originally Posted by Boissal

This is what I'm talking about with the fear. Dude's fucking shitting himself over the vaccine, terrified at the thought of getting it because he doesn't understand anything about it, yet is out there calling "libtards" pussies and probably thinks cause they live their lives in fear of the virus. This level of projection and cognitive dissonance should be fatal and yet, this twat is alive and well. Go figure...

---

I already had this Chinese-made super flu. I'm good, already. Thanks!!!

You people are the fucking worst thing to happen to this once beautiful nation. Letting your freedoms get fucking STRIPPED because you bought into the bullshit.

April 2020: "Two-week lock down will END this."
June 2020: "Oh shit .. that lock down didn't work ... let's do it again. I promise, it'll be different."
August 2020: "Let's do another lock down since it hasn't worked yet."
And again in September and November.

Fucking pussy ass fags.

Pathetic sheep you all are (well, not all ... a good number have some common fucking sense left).

Continue buying into the bullshit that this is only temporary. Trump is not the problem and never will be ... YOU ARE, fucking traitors.

https://uploads.tapatalk-cdn.com/202...97f3689160.jpg

Quote:

---

Originally Posted by GoldMember

Don't feed the trolls...

---

I have no intention of engaging with the guy, he clearly is confused and thinks this is 8Chan... Just using his schtick to illustrate my point about the loudest idiots usually being the ones who don't understand and are scared.

At first it sounded like BRO culture in action.

But like most of them, turns out it's just the Meth.

WTF is going on with this guy?

Quote:

---

Originally Posted by The AD

WTF is going on with this guy?

---

Stroke?

Bipolar episode?

Mushrooms?

Could be anything, really...

Quote:

---

Originally Posted by pappag

I already had this Chinese-made super flu. I'm good, already. Thanks!!!

You people are the fucking worst thing to happen to this once beautiful nation. Letting your freedoms get fucking STRIPPED because you bought into the bullshit.

April 2020: "Two-week lock down will END this."
June 2020: "Oh shit .. that lock down didn't work ... let's do it again. I promise, it'll be different."
August 2020: "Let's do another lock down since it hasn't worked yet."
And again in September and November.

Fucking pussy ass fags.

Pathetic sheep you all are (well, not all ... a good number have some common fucking sense left).

Continue buying into the bullshit that this is only temporary. Trump is not the problem and never will be ... YOU ARE, fucking traitors.

---

Lockdowns work, look at France for example, severe lockdown success end of October and new cases are way down

In the US, we had half assed lockdowns, not enforced.

Sent from my Redmi Note 8 Pro using Tapatalk

Quote:

---

Originally Posted by pappag

I already had this Chinese-made super flu. I'm good, already. Thanks!!!

You people are the fucking worst thing to happen to this once beautiful nation. Letting your freedoms get fucking STRIPPED because you bought into the bullshit.

April 2020: "Two-week lock down will END this."
June 2020: "Oh shit .. that lock down didn't work ... let's do it again. I promise, it'll be different."
August 2020: "Let's do another lock down since it hasn't worked yet."
And again in September and November.

Fucking pussy ass fags.

Pathetic sheep you all are (well, not all ... a good number have some common fucking sense left).

Continue buying into the bullshit that this is only temporary. Trump is not the problem and never will be ... YOU ARE, fucking traitors.

---

Go to PolyAss with this shit. I haven't seen anywhere that was saying who's the problem, other than the anti-vaxxers. You're the one bringing this in. Go away, troll.

Haha. Good entertainment here today.

That choad is likely upset he can’t run the fryer at his restaurant for a while and his mom is on his ass for rent.

I must say I am taking pleasure in these embarrassing meltdowns, especially the month long one from his dear leader.




Sent from my iPhone using TGR Forums

Quote:

---

Originally Posted by GoldMember

Don't feed the trolls...

---

Quote:

---

Originally Posted by GoldMember

Go to PolyAss with this shit. I haven't seen anywhere that was saying who's the problem, other than the anti-vaxxers. You're the one bringing this in. Go away, troll.

---

Hmmm....broke my own rule.

I guess if he's going to get banned he might as well go out in a blaze of glory.

Quote:

---

Originally Posted by The AD

I guess if he's going to get banned he might as well go out in a blaze of glory.

---

15 year member with over 6,000 posts. If he gets banned, I'll be shocked.

Quote:

---

Originally Posted by AK47bp

Haha. Good entertainment here today.

That choad is likely upset he can’t run the fryer at his restaurant for a while and his mom is on his ass for rent.

I must say I am taking pleasure in these embarrassing meltdowns, especially the month long one from his dear leader.




Sent from my iPhone using TGR Forums

---

I thought nickpappag was a dj and a yoga instructor

Quote:

---

Originally Posted by The AD

I guess if he's going to get banned he might as well go out in a blaze of glory.

---

Me get banned?

Yeah, okay.

Quote:

---

Originally Posted by abraham

I thought nickpappag was a dj and a yoga instructor

---

WAS being the key word. Not much use for DJs and in person yoga anymore. Hence the melt down prob?

Quote:

---

Originally Posted by abraham

I thought nickpappag was a dj and a yoga instructor

---

Even worse. Isn’t every loser a DJ?


Sent from my iPhone using TGR Forums

Quote:

---

Originally Posted by AK47bp

Even worse. Isn’t every loser a DJ?


Sent from my iPhone using TGR Forums

---

You able to see your dick when you pee, or do you still weigh 400 pounds and have a very terribly depressing life?

Quote:

---

Originally Posted by abraham

I thought nickpappag was a dj and a yoga instructor

---

Seems like his journey toward moksha has been knocked back a few steps.

Dude is super confused. As expected I guess.


Sent from my iPhone using TGR Forums

Quote:

---

Originally Posted by GoldMember

15 year member with over 6,000 posts. If he gets banned, I'll be shocked.

---

Yeah but I can't remember a thing he posted until this episode. Drawing a blank.

Quote:

---

Originally Posted by ötzi

Yeah but I can't remember a thing he posted until this episode. Drawing a blank.

---

True. Me neither.

Quote:

---

Originally Posted by ötzi

Yeah but I can't remember a thing he posted until this episode. Drawing a blank.

---

Yeah but you’ll remember this. Added to ignore.

Quote:

---

Originally Posted by ötzi

Yeah but I can't remember a thing he posted until this episode. Drawing a blank.

---

Cryogenics via glacier is presumed to have that effect.

Quote:

---

Originally Posted by ötzi

Yeah but I can't remember a thing he posted until this episode. Drawing a blank.

---

7,000 posts?

Why did admins allow user name changes
He had to have another name.

Back to rna, the bright side could be its safer than traditional vax since you’re only introducing (via replication) spike proteins?

Question? Why such quick reactions by some with allergies?
I would think replication would take some time after im injection.
And yet Uk is requiring injection sites have rescue equipment.

Is it adjuvants or something in the rna delivery soup?

Quote:

---

Originally Posted by Core Shot

7,000 posts?

Why did admins allow user name changes
He had to have another name.

Back to rna, the bright side could be its safer than traditional vax since you’re only introducing (via replication) spike proteins?

Question? Why such quick reactions by some with allergies?
I would think replication would take some time after im injection.
And yet Uk is requiring injection sites have rescue equipment.

Is it adjuvants or something in the rna delivery soup?

---

I actually posted SKIING stoke around here.

Do people even ski on this forum or is all a bunch of old pussies?

Quote:

---

Originally Posted by BCMtnHound

Cryogenics via glacier is presumed to have that effect.

---

Well that and bleeding out from an arrow. Can't be good for the brain.