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My comment wasn’t an attack or criticism of you or your hematuria or it’s relation to your vaccinations. Just saying that “hematuria” is not rare - there is a whole spectrum from benign to serious causes.
Acute interstitial nephritis has been known to occur post vaccination:
https://casereports.bmj.com/content/15/5/e246841
That was my thought…some sort of antigen based nephritis. Kinda crazy, and certainly in his case, seems correlated.Quote:
Originally Posted by bennymac
More evidence: pretty interesting, and while rare, certainly reinforces my thought of do I really need another booster that offers marginal protection? In my case, no.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059008/
The problem of "post hoc ergo propter hoc" is kind of baked into an initial look like that, but the authors kind of try to defuse that by saying their results don't support vaccine hesitancy. Of course, they could be wrong.Quote:
Originally Posted by Trackhead
The relevant information would be the relative risk ratio for these symptoms and conditions with and without vaccination. How often do they occur after disease or with neither vaccine or virus? But they excluded anyone with signs of infection and anyone with neither, so there isn't even any data to compare.
I'm eligible for another boost and haven't gotten it yet. I don't see the point in another exposure to the OG spike that's effectively or literally extinct at this point, but if there's an omicron+ (only) booster I expect to get it. All evidence I'm seeing (which does seem thin) still points to worse outcomes from virus than vaccine. My own experiences thus far have been 100-500x worse with virus than vaccine. So seeing medical professionals getting hesitant about vaccines makes a good case for masks, which continue to improve. Thanks for that!
Thanks for the response.Quote:
Originally Posted by Mofro261
That March 2023 Science article is pretty interesting, like the characterization omicron as a different virus (I’ve seen people sometimes describe it as “sars-cov-3”) and the trickiness of making meaningful conclusions from the data. It seems like a lot of the studies and data were up to June 2022, before the large summer 2022 wave, the issuance of the bivalent booster vax, and the waves in the fall 2022 and winter 2023. It’d be interesting to see updated data as that could provide meaningful information about benefits of the next booster.
Iwasaki indicates that the risk is too high for her personal comfort level. She gave an NPR interview last spring and mentioned that her age (middle age) and gender puts her in a vulnerable demographic for long covid.
It is troubling seeing and knowing people that have not recovered and considering that it could happen to you, too.
Thanks for the updates. I'm still avoiding indoor spaces, as a 5% risk of long covid sounds too high for someone who enjoys athletic pursuits.
That's said, it's time to see doctors for various checkups. My plan is the get the bivalent booster (I haven't had one) hoping that gives temporary protection vs infection for a couple months. Anyone know if it does?
(I skipped the bivalent because going indoors at a pharmacy seemed higher risk than skipping, and there were no outdoor options)
For sure get more boosters!
I don’t mean to marginalize the long covid risk, but I think for me personally, based on what I see in ER and primary care, I don’t think the risk is remotely high enough to change anything in my life. Not trashing on people for making personal risk assessments for themselves, but I really don’t think booster after booster and avoiding public spaces is necessary.
I’ve got two shots and have had Covid twice.
I have no clue whether to get another booster or not. But I’m definitely back to life as normal before Covid. Well, a little more precaution but that’s it. I definitely got caught up in the pandemic hysteria but maybe that saved me more Covid infections, who knows.
Cool story bro.
I have been jabbed 3 times and cought covid twice. Both times were like a pretty solid flu. First time i had lingering fatigue issues for about 6 weeks after. Second time i am still dealing with brainfog/ADD type shit a few months later which i cant confirm is tied to covid or just other life shit going on.Quote:
Originally Posted by Buzzworthy
Either way i dont really see why i wouldnt just stack the covid vaccine ontop of the flu vaccine i get most winters.
The brain fog was startling and a major red flag for me since my income is majorly reliant on my brain functioning. I've never had anything like it. I literally could not retain a number in my brain for more than a few seconds.Quote:
Originally Posted by californiagrown
^^Im 51, I don’t need long covid to have those symptoms;)
At almost 65, I am way ahead of you.
Haven’t there been headlines about HC workers in the UK that are cutting back or leaving because of their own LC?
COVID attacks whatever your personal physiological Achilles heel happens to be. Add in the effects if increased heat, forever chemicals in the water tables, crappy food additives/preservatives, Round Up, etc..
It's no wonder that everyone feels like shit nowadays..
That was my recent experience, too. I had to stop working outright for a week or two at the end of March--and I don't remember which. Felt a bit better and then a resurgence ended my ski season, which is always nice.Quote:
Originally Posted by oldnew_guy
Contrasts pretty dramatically with my first omicron exposure that gave me a sniffle for less than a day when my wife was positive. Either the damn thing got a lot worse or it helped a lot to be a few weeks out from a half-Moderna the first time versus 7 months post-bivalent. Or both?
So when y’all are feeling ill, are you taking any personal measures to minimize spreading whatever you have to others and doing RATs to confirm whether it’s covid?
Found it. Pretty small sample size. I musta seen some headlines reporting on the bmj article. https://www.bmj.com/content/382/bmj.p1529Quote:
Originally Posted by bodywhomper
^^ I Covid test myself if I get sick. I test patients less and less, as often times it won’t change treatment at all. At this point asking patients if they’ve been covid vaccinated is essentially irrelevant.
We don’t wear masks at work, and the oncology unit I was a patient in no longer wears them. Patients still often times wear N95s in oncology infusion centers.
Yeah, I make liberal use of masks. The night before my wife tested positive I slept in a doubled-gaitor facing the other way and then we split the house and wore good masks in common areas for a couple weeks. My two PCRs were negative.Quote:
Originally Posted by bodywhomper
This last time I kinda let the recommendations get to me. Quarantined for the first stretch, started feeling better after a while and spent a day at a client's site (masked, still coughing a little), but let my guard down a bit when I left. My wife came down with it 3 days later and after a week I was flattened again.
Tests are hard to come by here these days.
If I quantified my risk management it would reflect happily wearing a good mask for at least twice as many hours as I'm willing to be sick in a given year (targeted to situations, obviously). So far I'm behind.
My wife is still wearing an N95 for her entire work days. She's convinced she caught it the first time the day she took it off for lunch with sniffly co-workers.
Did before Covid and definitely after. When I’m sick I stay home. Not looking to give my crud to anyone else, including family. I hole up in the guest room.Quote:
Originally Posted by bodywhomper
And this last time I felt crappy I tested for Covid. However my test expiration dates had passed. Negative but still holed up in guest room for 2 days till I felt better.
The country as decided that not getting sick is your responsibility. And we treat our frontline workers like shit, so they'll be at work spreading. In this environment, there's limited value in your personal efforts not to spread stuff. That said, I will stay away from others if I catch covid (and that's also my policy for colds).Quote:
Originally Posted by bodywhomper
I generally avoid indoors. Wear a mask if I have to go in briefly, e.g. to pick up a pizza. I mostly visit people outdoors. If I've been indoors and I'm visiting my parents, I'll usually test to protect them. Occasionally I break my rules. I've acquired no respiratory disease this decade and I like it this way. Sometimes I miss walking to a local restaurant.
And yet there's 8 fucking billion of us.Quote:
Originally Posted by SumJongGuy
When I got Covid in Feb I stayed home for 5, wore a mask for 5 more. Missed 10 days of storm skiing/storm closures but I did get to shovel a ton of snow (literally). I was asymptomatic after 24 from starting Paxlovid. I caught it from my wife who caught it from our nieces family who she spent a week with and who were too dumb to tell her they were sick before she flew down there. So wearing a mask in public wouldn't have helped. I test if I feel sick. With this event I tested neg day 1, pos day 2. The only time I wear a mask other than when I was sick was when I go to Kaiser which still requires (but Tahoe Forest ER doesn't), when my allergies are bad, or when the smoke is bad.
https://www.cnn.com/2023/07/18/polit...ing/index.html
In Monday’s memorandum, HHS’s deputy assistant secretary for acquisition concludes that the Wuhan Institute’s “disregard of the NIH’s requests” and the NIH’s conclusion that the institute’s research likely violated biosafety protocols present a risk that the institute “not only previously violated, but is currently violating, and will continue to violate, protocols of the NIH on biosafety.”
My office manager just recovered from Covid Round 3. Had the initial vax and two boosters. No contact w/ anyone for 5 days.
I’m around confirmed covid positive people all the time. I’ve not tested positive for covid ever despite numerous tests for work, international travel, mild illnesses etc.
I’ve had two vax and two boosters. Something tells me they are working.
According to RFK jr it's because you're either Jewish or Chinese.Quote:
Originally Posted by bennymac
I've had four shots and haven't caught it (unless I was asymptomatic) either. Multiple exposures, including family members within the household having it.
So how do you explain the guy mentioned above who's had three shots and yet caught covid three times? Are the shots working for you but not for him?Quote:
Originally Posted by bennymac
Yep.Quote:
Originally Posted by yeahman
Well isn't that special.Quote:
Originally Posted by skaredshtles
Maybe you guys are part of the 10-15% of the population who are genetically HLA-B*15:01, and have a level of pre-existing immunity from previous infection with other non-SARS Coronaviruses that cause common colds, that leads to asymptomatic infection with Sars-2.
https://www.nature.com/articles/s41586-023-06331-x
A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection
Quote:
Abstract
Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2 remain asymptomatic1,2,3,4. Although most global efforts have focused on severe illness in COVID-19, examining asymptomatic infection provides a unique opportunity to consider early immunological features that promote rapid viral clearance. Here, postulating that variation in the human leukocyte antigen (HLA) loci may underly processes mediating asymptomatic infection, we enrolled 29,947 individuals, for whom high-resolution HLA genotyping data were available, in a smartphone-based study designed to track COVID-19 symptoms and outcomes. Our discovery cohort (n = 1,428) comprised unvaccinated individuals who reported a positive test result for SARS-CoV-2. We tested for association of five HLA loci with disease course and identified a strong association between HLA-B*15:01 and asymptomatic infection, observed in two independent cohorts. Suggesting that this genetic association is due to pre-existing T cell immunity, we show that T cells from pre-pandemic samples from individuals carrying HLA-B*15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF. The majority of the reactive T cells displayed a memory phenotype, were highly polyfunctional and were cross-reactive to a peptide derived from seasonal coronaviruses. The crystal structure of HLA-B*15:01–peptide complexes demonstrates that the peptides NQKLIANQF and NQKLIANAF (from OC43-CoV and HKU1-CoV) share a similar ability to be stabilized and presented by HLA-B*15:01. Finally, we show that the structural similarity of the peptides underpins T cell cross-reactivity of high-affinity public T cell receptors, providing the molecular basis for HLA-B*15:01-mediated pre-existing immunity.
If you’re only satisfied with perfection then you’re gonna go through life very sad and disappointed.Quote:
Originally Posted by yeahman
Maybe that person should try doing what all the antivaxxers were screaming about and live a healthier life?
Not my job to explain anecdotal stories - the data at a population level is very clear about how effective the vaccines are.
No vaccines have ever been 100% successful - if that’s not good enough for people then they must be unhappy with everything on the planet and therefore are beyond reach. Vibes.
I have also managed to avoid it as has my immediate family. Just about all our friends and extended family have had someone in their households get it.
Quote:
Originally Posted by bennymac
https://www.theatlantic.com/science/...ccines/620023/
I’m on 6 Covid shots total, 2 of them Bivalent. All Pfizer. I don’t mask anymore, I’m going about my life as normal. I go in crowded indoor spaces without worry.Quote:
Originally Posted by yeahman
I’ve never been infected with Covid. All my boosters give me the freedom to enjoy my life, and not cower in fear.
I use Mayo Clinic as my primary care, and they are the ones who recommended shot #6. I’ll get shot #7 when my Mayo Clinic doc recommends it.
Wouldn’t my 4 covid vax doses make me more likely to have asymptomatic covid infections - more so than any genetic anomaly and/or pre-immunity from previous infection with other coronaviruses?Quote:
Originally Posted by Mofro261
So basically you're saying your vaccinations are NOT the reason you haven't caught covid. It's because you live a "healthier life."Quote:
Originally Posted by bennymac
Try reading it again. Take Tylenol if you get any headaches.Quote:
Originally Posted by yeahman
We don’t live in a binary world. A person can get vaccinated AND live a healthy life - that’s gonna offers more protection than just one or the other - or neither.
You should ask your parents and schoolteachers why you never learned how to think and appraise at a level beyond a 10 year old if this simple matter is that difficult for you to wrap your head around.
Hadn't thought about Covid for a while until daughter got it.
Nice thing about not thinking about covid is that you are generally not thinking about science deniers and antivaxers either.
Whoever said that curing disease would be easier than curing dumb was right on the money.
Amen. We cure diseases all the time. So much so that it allows dumb people to think their dumb behaviors are healthy - and these dumb people then raise dumb kids. They also post dumb shit online that they think says something relevant.Quote:
Originally Posted by berko